5-(4-chloro-phenyl)-6-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridin-3-ylamine

Base Information

Chemical Name:5-(4-chloro-phenyl)-6-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridin-3-ylamine
CAS No.:1372606-96-6
Molecular Formula:C₁₄H₁₂ClF₃N₂O
Molecular Weight:316.71
Hs Code.:

Synonyms:5-(4-chloro-phenyl)-6-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridin-3-ylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(4-chloro-phenyl)-6-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridin-3-ylamine

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Technology Process of 5-(4-chloro-phenyl)-6-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridin-3-ylamine

There total 8 articles about 5-(4-chloro-phenyl)-6-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridin-3-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1372606-94-4
[5-(4-Chloro-phenyl)-6-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridin-3-yl]-carbamic acid tert-butyl ester

: 1372606-96-6
5-(4-chloro-phenyl)-6-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridin-3-ylamine

Guidance literature:: [5-(4-Chloro-phenyl)-6-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridin-3-yl]-carbamic acid tert-butyl ester; With trifluoroacetic acid; at 20 ℃; for 1h;

With sodium carbonate; In water; ethyl acetate;

Reference yield: 82.0%

: (S)-tert-butyl 5-(4-chlorophenyl)-6-(1,1,1-trifluoropropan-2-yloxy)pyridin-3-ylcarbamate

: 1372606-96-6
5-(4-chloro-phenyl)-6-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridin-3-ylamine

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 1h;

Reference yield:

: 1364677-73-5
5-chloro-3-(4-chloro-phenyl)-2-fluoro-pyridine

: 1372606-96-6
5-(4-chloro-phenyl)-6-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridin-3-ylamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

1.2: 2 h / 20 °C

2.1: triethylamine / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 20 h / 150 °C / 52505.3 Torr

3.1: water; lithium hydroxide / tetrahydrofuran / 20 °C

3.2: pH 2

4.1: diphenyl phosphoryl azide; triethylamine / 100 °C

5.1: trifluoroacetic acid / 1 h / 20 °C

With diphenyl phosphoryl azide; water; sodium hydride; triethylamine; trifluoroacetic acid; lithium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; N,N-dimethyl-formamide;