5-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeroylamino]-phthalide

Base Information

Chemical Name:5-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeroylamino]-phthalide
CAS No.:217193-92-5
Molecular Formula:C₂₂H₂₁F₄NO₅
Molecular Weight:455.406
Hs Code.:

Synonyms:5-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeroylamino]-phthalide

Suppliers and Price of 5-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeroylamino]-phthalide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeroylamino]-phthalide

Chemical Property:

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Technology Process of 5-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeroylamino]-phthalide

There total 8 articles about 5-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeroylamino]-phthalide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 959844-08-7
(trifluoro methyl) magnesiumbromide

: 934391-82-9
4-(5-fluoro-2-methoxy-phenyl)-4-methyl-2-oxo-pentanoic acid (1-oxo-1,3-dihydro-isobenzofuran-5-yl)-amide

: 217193-92-5
5-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeroylamino]-phthalide

Guidance literature:: at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2005.07.025

Reference yield:

: 65399-05-5
5-amino-3H-isobenzofuran-1-one

: C₁₄H₁₅ClF₄O₃

: 217193-92-5
5-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeroylamino]-phthalide

Guidance literature:

Reference yield:

: 217196-31-1
4-(5-fluoro-2-methoxyphenyl)-4-methyl-2-oxopentanoic acid

: 217193-92-5
5-[4-(5-fluoro-2-methoxyphenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-valeroylamino]-phthalide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / N,N-dimethyl-acetamide / 0 °C

2: N,N-dimethyl-acetamide / 0 - 20 °C

3: 60 percent / 0 - 20 °C

With thionyl chloride; In N,N-dimethyl acetamide;
DOI:10.1016/j.bmcl.2005.07.025