Technology Process of tert-butyl (2S,4S,7RS)-4-(2-hydroxy-3-O-tert-butyldiphenylsilyloxypropyl)-pyroglutamate
There total 3 articles about tert-butyl (2S,4S,7RS)-4-(2-hydroxy-3-O-tert-butyldiphenylsilyloxypropyl)-pyroglutamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 44 percent / lithium hexamethyldisilazide / tetrahydrofuran / 2 h / -78 °C
2: 100 percent / 1M HCl / ethyl acetate / 23 h / Ambient temperature
3: 87 percent / K3Fe(CN)6, K2CO3, OsO4 / 2-methyl-propan-2-ol; H2O / 15 h / Ambient temperature
4: 63 percent / DMAP, Et3N / CH2Cl2 / 44 h / Ambient temperature
With
hydrogenchloride; dmap; osmium(VIII) oxide; potassium carbonate; triethylamine; lithium hexamethyldisilazane; potassium hexacyanoferrate(III);
In
tetrahydrofuran; dichloromethane; water; ethyl acetate; tert-butyl alcohol;
DOI:10.1016/S0040-4020(99)00403-2
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 87 percent / K3Fe(CN)6, K2CO3, OsO4 / 2-methyl-propan-2-ol; H2O / 15 h / Ambient temperature
2: 63 percent / DMAP, Et3N / CH2Cl2 / 44 h / Ambient temperature
With
dmap; osmium(VIII) oxide; potassium carbonate; triethylamine; potassium hexacyanoferrate(III);
In
dichloromethane; water; tert-butyl alcohol;
DOI:10.1016/S0040-4020(99)00403-2
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 100 percent / 1M HCl / ethyl acetate / 23 h / Ambient temperature
2: 87 percent / K3Fe(CN)6, K2CO3, OsO4 / 2-methyl-propan-2-ol; H2O / 15 h / Ambient temperature
3: 63 percent / DMAP, Et3N / CH2Cl2 / 44 h / Ambient temperature
With
hydrogenchloride; dmap; osmium(VIII) oxide; potassium carbonate; triethylamine; potassium hexacyanoferrate(III);
In
dichloromethane; water; ethyl acetate; tert-butyl alcohol;
DOI:10.1016/S0040-4020(99)00403-2