1-{5-tert-butyl-2-[3-(2-dimethylamino-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-(cis-2,6-dimethyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea formate salt

Base Information

Chemical Name:1-{5-tert-butyl-2-[3-(2-dimethylamino-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-(cis-2,6-dimethyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea formate salt
CAS No.:1443240-87-6
Molecular Formula:CH₂O₂*C₄₁H₅₃N₉O₃
Molecular Weight:765.956
Hs Code.:

1-{5-tert-butyl-2-[3-(2-dimethylamino-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-(cis-2,6-dimethyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea formate salt

Synonyms:1-{5-tert-butyl-2-[3-(2-dimethylamino-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-(cis-2,6-dimethyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea formate salt

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Chemical Property of 1-{5-tert-butyl-2-[3-(2-dimethylamino-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-(cis-2,6-dimethyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea formate salt

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Technology Process of 1-{5-tert-butyl-2-[3-(2-dimethylamino-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-(cis-2,6-dimethyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea formate salt

There total 18 articles about 1-{5-tert-butyl-2-[3-(2-dimethylamino-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-(cis-2,6-dimethyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea formate salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82560-12-1,1237537-54-0
3-tert-butyl-1H-pyrazole-5-amine

: 1443240-87-6
1-{5-tert-butyl-2-[3-(2-dimethylamino-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-(cis-2,6-dimethyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea formate salt

Guidance literature:: Multi-step reaction with 7 steps

1: copper(l) iodide; cis-N,N'-dimethyl-1,2-diaminocyclohexane; potassium carbonate / toluene / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / 72 h

3: sodium hydroxide / water; ethyl acetate / 1 h / 20 °C

4: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 70 °C

5: pyridinium p-toluenesulfonate / methanol / 3.5 h / 60 °C

6: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / Cooling with ice

7: tetrahydrofuran / 50 °C / Sealed tube

With copper(l) iodide; di-isopropyl azodicarboxylate; pyridinium p-toluenesulfonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; cis-N,N'-dimethyl-1,2-diaminocyclohexane; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate; toluene;

Reference yield:

: 1443242-59-8
2,2,2-trifluoro-N-((1S,4R)-4-hydroxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-acetamide

: 1443240-87-6
1-{5-tert-butyl-2-[3-(2-dimethylamino-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-(cis-2,6-dimethyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea formate salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / methanol; water / 3.5 h

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h

2.2: 1 h / 60 °C

3.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 70 °C

4.1: pyridinium p-toluenesulfonate / methanol / 3.5 h / 60 °C

5.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / Cooling with ice

6.1: tetrahydrofuran / 50 °C / Sealed tube

With pyridinium p-toluenesulfonate; sodium hydride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 1351997-20-0
(1R,4S)-aminoN-(S)-4-hydroxy-1,2,3,4-tetrahydronaphthalen-1-ol

: 1443240-87-6
1-{5-tert-butyl-2-[3-(2-dimethylamino-ethoxy)-phenyl]-2H-pyrazol-3-yl}-3-{(1S,4R)-4-[3-(cis-2,6-dimethyl-piperidin-1-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea formate salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h

1.2: 1 h / 60 °C

2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 70 °C

3.1: pyridinium p-toluenesulfonate / methanol / 3.5 h / 60 °C

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / Cooling with ice

5.1: tetrahydrofuran / 50 °C / Sealed tube

With pyridinium p-toluenesulfonate; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;