1-(2,5-dimethoxyphenyl)cyclohexene oxide

Base Information

• Chemical Name: 1-(2,5-dimethoxyphenyl)cyclohexene oxide
• CAS No.: 99344-01-1
• Molecular Formula: C₁₄H₁₈O₃
• Molecular Weight: 234.295
• Mol file: 99344-01-1.mol

Synonyms:1-(2,5-dimethoxyphenyl)cyclohexene oxide

Chemical Property of 1-(2,5-dimethoxyphenyl)cyclohexene oxide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-(2,5-dimethoxyphenyl)cyclohexene oxide

There total 3 articles about 1-(2,5-dimethoxyphenyl)cyclohexene oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-(2,5-dimethoxyphenyl)cyclohexene (1848-14-2) → 1-(2,5-dimethoxyphenyl)cyclohexene oxide (99344-01-1)

Guidance literature:

With sodium fluoride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -5 ℃; for 0.5h;

Reference yield:

1-(2,5-dimethoxyphenyl)cyclohexene (1848-14-2) → (1R,6R)-1-(2,5-Dimethoxy-phenyl)-7-oxa-bicyclo[4.1.0]heptane (99344-01-1)

Guidance literature:

With sodium fluoride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1016/0223-5234(88)90164-X

Reference yield:

cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-(2,5-dimethoxyphenyl)cyclohexene oxide (99344-01-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 41 percent / Mg, I₂ / diethyl ether / Ambient temperature

2: 87 percent / sodium fluoride, m-chloroperbenzoic acid / CH₂Cl₂ / 0.5 h / -5 °C

With iodine; sodium fluoride; magnesium; 3-chloro-benzenecarboperoxoic acid; In diethyl ether; dichloromethane;

upstream raw materials:

1-(2,5-dimethoxyphenyl)cyclohexene

cyclohexanone

Downstream raw materials:

trans-1-(2,5-dimethoxyphenyl)-2-isopropylaminocyclohexanol

trans-1-(2,5-dimethoxyphenyl)-2-isopropylaminocyclohexanol hydrochloride

trans-2-amino-1-(2,5-dimethoxyphenyl)cyclohexanol hydrochloride