3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)isoquinolin-1-yl)benzoyl chloride

Base Information

Chemical Name:3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)isoquinolin-1-yl)benzoyl chloride
CAS No.:1152274-56-0
Molecular Formula:C₂₇H₁₇ClF₂N₂O₄
Molecular Weight:506.893
Hs Code.:

Synonyms:3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)isoquinolin-1-yl)benzoyl chloride

Suppliers and Price of 3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)isoquinolin-1-yl)benzoyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)isoquinolin-1-yl)benzoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)isoquinolin-1-yl)benzoyl chloride

There total 11 articles about 3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)isoquinolin-1-yl)benzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)isoquinolin-1-yl)benzoic acid trifluoroacetate

: 1152274-56-0
3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)isoquinolin-1-yl)benzoyl chloride

Guidance literature:: With thionyl chloride; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

Reference yield:

: 68119-31-3
2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile

: 1152274-56-0
3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)isoquinolin-1-yl)benzoyl chloride

Guidance literature:: Multi-step reaction with 7 steps

1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water / 70 °C

2: sodium hydroxide; water / 2.5 h / Heating / reflux

3: thionyl chloride / N,N-dimethyl-formamide / 2 h / 20 °C

4: triethylamine / dichloromethane / 18 h / 20 °C

5: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 80 °C

6: dichloromethane / 3.5 h / 20 °C

7: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

With sodium hydroxide; thionyl chloride; N-benzyl-N,N,N-triethylammonium chloride; water; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 72768-97-9
(2,2-difluoro-1,3-benzodioxol-5-yl)methanol

: 1152274-56-0
3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)isoquinolin-1-yl)benzoyl chloride

Guidance literature:: Multi-step reaction with 9 steps

1: thionyl chloride / dichloromethane / 0 - 20 °C

2: dimethyl sulfoxide / 20 °C

3: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / water / 70 °C

4: sodium hydroxide; water / 2.5 h / Heating / reflux

5: thionyl chloride / N,N-dimethyl-formamide / 2 h / 20 °C

6: triethylamine / dichloromethane / 18 h / 20 °C

7: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 80 °C

8: dichloromethane / 3.5 h / 20 °C

9: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 0.5 h / 20 °C

With sodium hydroxide; thionyl chloride; N-benzyl-N,N,N-triethylammonium chloride; water; sodium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;