72768-97-9

Basic information

• Product Name: RARECHEM AL BD 0477
• Synonyms: RARECHEM AL BD 0477;(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHANOL;2,2-Difluoro-5-(hydroxymethyl)-1,3-benzodioxole;(2,2-Difluoro-benzo[1,3]dioxol-5-yl)-methanol;1,3-Benzodioxole-5-Methanol, 2,2-difluoro-;(2,2-difluoro-2H-1,3-benzodioxol-5-yl)methanol;RARECHEM AL BD 0477 (Related Reference)
• CAS NO: 72768-97-9
• Molecular Formula: C₈H₆F₂O₃
• Molecular Weight: 188.13
• Mol File: 72768-97-9.mol
• Article Data: 38

Chemical Properties

• Boiling Point: 229.145°C at 760 mmHg
• Flash Point: 113.298°C
• Appearance: /
• Density: 1.513g/cm³
• Vapor Pressure: 0.04mmHg at 25°C
• Refractive Index: 1.544
• Storage Temp.: 2-8°C
• PKA: 14.24±0.10(Predicted)
• CAS DataBase Reference: RARECHEM AL BD 0477(CAS DataBase Reference)
• NIST Chemistry Reference: RARECHEM AL BD 0477(72768-97-9)
• EPA Substance Registry System: RARECHEM AL BD 0477(72768-97-9)

Safety Data

• RIDADR: UN2811
• Hazardous Substances Data: 72768-97-9(Hazardous Substances Data)

Usage

General Description

RARECHEM AL BD 0477 is a chemical compound consisting of aluminum bromide (AlBr3). It is a white to off-white crystalline powder that is highly reactive and often used as a catalyst in various chemical reactions, such as Friedel-Crafts alkylation and acylation processes. Aluminum bromide is also known for its use in organic synthesis, particularly in the production of pharmaceuticals and agrochemicals. Due to its reactivity and potential hazards, it must be handled with care and under specific conditions to avoid accidents or chemical reactions.

InChI:InChI=1/C8H6F2O3/c9-8(10)12-6-2-1-5(4-11)3-7(6)13-8/h1-3,11H,4H2

Upstream product

• 33070-32-5 5-bromo-2,2-difluoro-2H-1,3-benzodioxole 
• 656-46-2 2,2-difluoro-1,3-benzodioxole-5-carboxylic acid 
• 1583-59-1 2,2-difluoro-1,3-benzodioxole 
• 656-42-8 2,2-difluoro-2H-1,3-benzodioxole-5-carbaldehyde 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 
• 110-85-0 piperazine 
• 773873-95-3 2,2-difluorobenzo[1,3]dioxole-5-carboxylic acid methyl ester 

Downstream Products

• 476473-97-9 5-chloromethyl-2,2-difluoro-benzo[1,3]dioxole 
• 68119-31-3 2-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)acetonitrile 
• 1152274-48-0 2-(3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane carboxamido)isoquinolin-1-yl)benzoyloxy)-N,N,N-trimethylethanaminium chloride 
• 1152274-36-6 2-(dimethylamino)ethyl 3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)isoquinolin-1-yl)benzoate 
• 1152274-55-9 tert-butyl 3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)isoquinolin-1-yl)benzoate 
• 1152274-47-9 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(4-(hydroxymethyl)phenyl)isoquinolin-3-yl)cyclopropanecarboxamide 
• 1152274-56-0 3-(3-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamido)isoquinolin-1-yl)benzoyl chloride 
• 1083168-21-1 N-(6-(1-(2-cyanamido-2-oxoethyl)-6-oxo-1,6-dihydropyridin-3-yl)-5-methylpyridin-2-yl)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropanecarboxamide 
• 1083168-23-3 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(6-(5-fluoro-2-oxo-1,2-dihydropyridin-4-yl)-5-methylpyridin-2-yl)cyclopropanecarboxamide 
• 1160221-26-0 Lumacaftor hydrochloride 
• 936727-05-8 Lumacaftor 
• 1160221-25-9 tert-butyl 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)cyclopropane-1-carboxamido)-3-methylpyridin-2-yl)benzoate 
• 1294504-68-9 N-{1-[(2R)-3-(benzyloxy)-2-hydroxypropyl]-2-[1-(benzyloxy)-2-methylpropan-2-yl]-6-fluoro-1H-indol-5-yl}-1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropane-1-carboxamide 
• 1152311-62-0 (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide 

Relevant articles and documents

PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS

Compounds of the formula (I) wherein Q is as defined in claim 1. Furthermore, the present invention relates to agrochemical compositions which comprise compounds of formula (I), to preparation of these compositions, and to the use of the compounds or compositions in agriculture or horticulture for combating, preventing or controlling animal pests, including arthropods and in particular insects, molluscs, nematodes or representatives of the order Acarina.

METHODS OF TREATMENT FOR CYSTIC FIBROSIS

This application describes methods of treating cystic fibrosis or a CFTR mediated disease comprising administering Compound I or a pharmaceutically acceptable salt thereof. (I) The application also describes pharmaceutical compositions comprising Compound I or a pharmaceutically acceptable salt thereof and optionally comprising one or more additional CFTR modulating agents.

Synthesis method of (2,2-difluorobenzo[d][1,3]dioxy-5-yl)methanol

The invention discloses a preparation method of (2,2-difluorobenzo[d][1,3]dioxo-5-yl)methanol as a fine chemical intermediate. The method is simple and feasible, lower in cost, and suitable for preparing (2,2-difluorobenzo[d][1,3]dioxo-5-yl)methanol through industrial production.