4,2'-difluoro-5'-(8-oxo-7,8-dihydroimidazo[1,2-a]pyrazin-3-yl)-biphenyl-2-carbonitrile

Base Information

Chemical Name:4,2'-difluoro-5'-(8-oxo-7,8-dihydroimidazo[1,2-a]pyrazin-3-yl)-biphenyl-2-carbonitrile
CAS No.:689297-98-1
Molecular Formula:C₁₉H₁₀F₂N₄O
Molecular Weight:348.311
Hs Code.:

Synonyms:4,2'-difluoro-5'-(8-oxo-7,8-dihydroimidazo[1,2-a]pyrazin-3-yl)-biphenyl-2-carbonitrile

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Chemical Property of 4,2'-difluoro-5'-(8-oxo-7,8-dihydroimidazo[1,2-a]pyrazin-3-yl)-biphenyl-2-carbonitrile

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Technology Process of 4,2'-difluoro-5'-(8-oxo-7,8-dihydroimidazo[1,2-a]pyrazin-3-yl)-biphenyl-2-carbonitrile

There total 13 articles about 4,2'-difluoro-5'-(8-oxo-7,8-dihydroimidazo[1,2-a]pyrazin-3-yl)-biphenyl-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 425378-83-2
5'-bromo-2',4-difluorobiphenyl-2-carbonitrile

: 689297-94-7
8-oxo-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazine hydrochloride

: 689297-98-1
4,2'-difluoro-5'-(8-oxo-7,8-dihydroimidazo[1,2-a]pyrazin-3-yl)-biphenyl-2-carbonitrile

Guidance literature:: With potassium acetate; triphenylphosphine; palladium diacetate; In 2,4-dichlorophenoxyacetic acid dimethylamine; at 130 ℃; for 3h;

Reference yield:

: 69214-33-1
8-chloroimidazo[1,2-α]pyrazine

: 689297-98-1
4,2'-difluoro-5'-(8-oxo-7,8-dihydroimidazo[1,2-a]pyrazin-3-yl)-biphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / Br₂; KBr; NaOAc / methanol / 0 °C

2: Cs₂CO₃; Pd(PPh₃)4 / tetrahydrofuran / Heating

3: methanol; CH₂Cl₂ / 40 °C

4: HBr; AcOH / 95 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen bromide; bromine; sodium acetate; caesium carbonate; acetic acid; potassium bromide; In tetrahydrofuran; methanol; dichloromethane; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2005.12.027

Reference yield:

: 689297-88-9
8-oxo-7,8-dihydroimidazo[1,2-a]pyrazine hydrochloride

: 689297-98-1
4,2'-difluoro-5'-(8-oxo-7,8-dihydroimidazo[1,2-a]pyrazin-3-yl)-biphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 408 h / 2844.39 Torr

2: potassium acetate; triphenylphosphine / palladium diacetate / 2,4-dichlorophenoxyacetic acid dimethylamine / 3 h / 130 °C

With hydrogen; potassium acetate; triphenylphosphine; palladium 10% on activated carbon; palladium diacetate; In methanol; 2,4-dichlorophenoxyacetic acid dimethylamine;