69214-33-1

Basic information

• Product Name: 8-Chloro-imidazo[1,2-a]pyrazine
• Synonyms: 8-Chloro-imidazo[1,2-a]pyrazine
• CAS NO: 69214-33-1
• Molecular Formula: C₆H₄ClN₃
• Molecular Weight: 153.56906
• Mol File: 69214-33-1.mol
• Article Data: 24

Chemical Properties

• Appearance: /
• Density: 1.51±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 1.50±0.30(Predicted)
• CAS DataBase Reference: 8-Chloro-imidazo[1,2-a]pyrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Chloro-imidazo[1,2-a]pyrazine(69214-33-1)
• EPA Substance Registry System: 8-Chloro-imidazo[1,2-a]pyrazine(69214-33-1)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 69214-33-1(Hazardous Substances Data)

Usage

Uses

8-Chloroimidazo[1,2-a]pyrazine is a useful research chemical.

Upstream product

• 6863-73-6 3-chloropyrazin-2-amine 
• 17157-48-1 bromoacetaldehyde 
• 107-20-0 2-chloroethanal 
• 7252-83-7 1-bromo-2,2-dimethoxyethane 
• 3400-56-4 α-bromobutyraldehyde diethyl acetal 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 

Downstream Products

• 1383102-53-1 N-cyclopropyl-3-methyl-4-{8-[(2-methylpropyl)amino]imidazo[1,2-a]pyrazin-3-yl}benzamide 
• 1613021-34-3 1-(2-fluorophenyl)-N-[(3S)-1-imidazo[1,2-a]pyrazin-8-ylpyrrolidin-3-yl]-1,2,4-triazole-3-carboxamide trifluoroacetate 
• 1613023-19-0 N-[(3S)-1-imidazo[1,2-a]pyrazin-8-ylpyrrolidin-3-yl]-1-(4-iodophenyl)-1,2,4-triazole-3-carboxamide 
• 1613021-36-5 N-[(3S)-1-imidazo[1,2-a]pyrazin-8-ylpyrrolidin-3-yl]-1-(4-methylsulfonylphenyl)-1,2,4-triazole-3-carboxamide trifluoroacetate 
• 1613021-38-7 N-[(3S)-1-imidazo[1,2-a]pyrazin-8-ylpyrrolidin-3-yl]-1-(p-tolyl)-1,2,4-triazole-3-carboxamide trifluoroacetate salt 
• 1613021-41-2 1-(4-cyanophenyl)-N-[(3S)-1-imidazo[1,2-a]pyrazin-8-ylpyrrolidin-3-yl]-1,2,4-triazole-3-carboxamide 
• 1613021-46-7 1-(4-fluorophenyl)-N-[(3S)-3-(hydroxymethyl)-1-imidazo[1,2-a]pyrazin-8-yl-pyrrolidin-3-yl]pyrazole-3-carboxamide 
• 1613021-48-9 N-[(3S)-3-(hydroxymethyl)-1-imidazo[1,2-a]pyrazin-8-yl-pyrrolidin-3-yl]-1-phenyl-1,2,4-triazole-3-carboxamide 
• 1613021-60-5 1-(4-fluorophenyl)-N-[(3S)-1-imidazo[1,2-a]pyrazin-8-ylpyrrolidin-3-yl]-5-methyl-1,2,4-triazole-3-carboxamide 
• 1613021-92-3 (S)-N-(1-(imidazo[1,2-a]pyrazin-8-yl)pyrrolidin-3-yl)-1-phenyl-1H-1,2,4-triazole-3-carboxamide 
• 1613021-93-4 (S)-1-(4-fluorophenyl)-N-(1-(imidazo[1,2-a]pyrazin-8-yl)pyrrolidin-3-yl)-1H-1,2,4-triazole-3-carboxamide 
• 1613021-94-5 (S)-1-(3-fluorophenyl)-N-(1-(imidazo[1,2-a]pyrazin-8-yl)pyrrolidin-3-yl)-1H-1,2,4-triazole-3-carboxamide 
• 1613022-17-5 C₂₀H₁₈N₆O₂*C₂HF₃O₂ 
• 1613022-94-8 C₂₀H₁₈N₆OS*C₂HF₃O₂ 

Relevant articles and documents

SUBSTITUTED FUSED AROMATIC RING DERIVATIVE, COMPOSITION AND USE THEREOF

Provided are a substituted fused aromatic ring derivative, a composition containing the compound, and a use thereof. The substituted fused aromatic ring derivative is a compound represented by formula (I) or a tautomer, stereoisomer, prodrug, crystal form, pharmaceutically acceptable salt, hydrate or solvate thereof. The compound and the composition can be used to treat various protein tyrosine kinase-mediated diseases or disorders.

Selective Halogenation of Pyridines Using Designed Phosphine Reagents

Halopyridines are key building blocks for synthesizing pharmaceuticals, agrochemicals, and ligands for metal complexes, but strategies to selectively halogenate pyridine C-H precursors are lacking. We designed a set of heterocyclic phosphines that are installed at the 4-position of pyridines as phosphonium salts and then displaced with halide nucleophiles. A broad range of unactivated pyridines can be halogenated, and the method is viable for late-stage halogenation of complex pharmaceuticals. Computational studies indicate that C-halogen bond formation occurs via an SNAr pathway, and phosphine elimination is the rate-determining step. Steric interactions during C-P bond cleavage account for differences in reactivity between 2- and 3-substituted pyridines.

Alkynyl (hetero) aromatic compounds for inhibiting activity of protein kinase

The invention relates to alkynyl (hetero) aromatic compounds for inhibiting activity of protein tyrosine kinase. The invention further relates to a pharmaceutical composition containing the alkynyl (hetero) aromatic compounds, and preparation and application of the alkynyl (hetero) aromatic compounds. Specifically, the invention discloses the alkynyl (hetero) aromatic compound shown in an equation (I) and pharmaceutically acceptable salts, stereoisomers, solvates, hydrates, crystal forms, prodrugs and isotopic variants of the alkynyl (hetero) aromatic compound shown in the equation (I). The alkynyl (hetero) aromatic compounds can be used for treating and/or preventing protein tyrosine kinase-related diseases, such as preventing tumors.