(2,4-dihydroxy-5-isopropylphenyl)-(5-fluoro-1,3-dihydroisoindol-2-yl)-methanone

Base Information

• Chemical Name: (2,4-dihydroxy-5-isopropylphenyl)-(5-fluoro-1,3-dihydroisoindol-2-yl)-methanone
• CAS No.: 912999-23-6
• Molecular Formula: C₁₈H₁₈FNO₃
• Molecular Weight: 315.344

Synonyms:(2,4-dihydroxy-5-isopropylphenyl)-(5-fluoro-1,3-dihydroisoindol-2-yl)-methanone

Chemical Property of (2,4-dihydroxy-5-isopropylphenyl)-(5-fluoro-1,3-dihydroisoindol-2-yl)-methanone

Chemical Property:

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Technology Process of (2,4-dihydroxy-5-isopropylphenyl)-(5-fluoro-1,3-dihydroisoindol-2-yl)-methanone

There total 2 articles about (2,4-dihydroxy-5-isopropylphenyl)-(5-fluoro-1,3-dihydroisoindol-2-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C32H28FNO3 (1240325-50-1) → (2,4-dihydroxy-5-isopropylphenyl)-(5-fluoro-1,3-dihydroisoindol-2-yl)-methanone (912999-23-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 16h;

DOI:10.1021/jm100060b

Reference yield:

→ (2,4-dihydroxy-5-isopropylphenyl)-(5-fluoro-1,3-dihydroisoindol-2-yl)-methanone (912999-23-6)

Guidance literature:

Reference yield: 63.8%

(2,4-dihydroxy-5-isopropylphenyl)-(5-fluoro-1,3-dihydroisoindol-2-yl)-methanone (912999-23-6) + hexamethylenetetramine (100-97-0) → 3-(5-fluoroisoindoline-2-carbonyl)-2,6-dihydroxy-5-isopropylbenzaldehyde

Guidance literature:

(2,4-dihydroxy-5-isopropylphenyl)-(5-fluoro-1,3-dihydroisoindol-2-yl)-methanone; hexamethylenetetramine; With trifluoroacetic acid; at 100 ℃; for 14h; Sealed tube;

With hydrogenchloride; water; at 60 ℃; for 3h;

upstream raw materials:

C₃₂H₂₈FNO₃

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