N-(3-tert-butyldimethylsiloxy-5-ethoxypent-4-ynyl)benzene sulfonamide

Base Information

• Chemical Name: N-(3-tert-butyldimethylsiloxy-5-ethoxypent-4-ynyl)benzene sulfonamide
• CAS No.: 175026-38-7
• Molecular Formula: C₁₉H₃₁NO₄SSi
• Molecular Weight: 397.611
• Mol file: 175026-38-7.mol

Synonyms:N-(3-tert-butyldimethylsiloxy-5-ethoxypent-4-ynyl)benzene sulfonamide

Chemical Property of N-(3-tert-butyldimethylsiloxy-5-ethoxypent-4-ynyl)benzene sulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-tert-butyldimethylsiloxy-5-ethoxypent-4-ynyl)benzene sulfonamide

There total 3 articles about N-(3-tert-butyldimethylsiloxy-5-ethoxypent-4-ynyl)benzene sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

tert-butyldimethylsilyl chloride (18162-48-6) + N-(5-ethoxy-3-hydroxypent-4-ynyl)benzene sulfonamide (175026-34-3) → N-(3-tert-butyldimethylsiloxy-5-ethoxypent-4-ynyl)benzene sulfonamide (175026-38-7)

Guidance literature:

With 1H-imidazole; In tetrahydrofuran; for 12h; Ambient temperature;

Reference yield:

N-<3-Hydroxy-propyl>-benzolsulfonsaeure-amid (3351-94-8) → N-(3-tert-butyldimethylsiloxy-5-ethoxypent-4-ynyl)benzene sulfonamide (175026-38-7)

Guidance literature:

Multi-step reaction with 3 steps

1: oxalyl chloride, DMSO, triethylamine / CH₂Cl₂ / -78 °C / to RT

2: 50 percent / n-BuLi / tetrahydrofuran / -78 deg C, 30 min, -78 deg C to RT

3: 26 percent / imidazole / tetrahydrofuran / 12 h / Ambient temperature

With 1H-imidazole; n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

N-(3-oxopropyl)benzene sulfonamide (175026-30-9) → N-(3-tert-butyldimethylsiloxy-5-ethoxypent-4-ynyl)benzene sulfonamide (175026-38-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / n-BuLi / tetrahydrofuran / -78 deg C, 30 min, -78 deg C to RT

2: 26 percent / imidazole / tetrahydrofuran / 12 h / Ambient temperature

With 1H-imidazole; n-butyllithium; In tetrahydrofuran;

upstream raw materials:

tert-butyldimethylsilyl chloride

N-(5-ethoxy-3-hydroxypent-4-ynyl)benzene sulfonamide

N-<3-Hydroxy-propyl>-benzolsulfonsaeure-amid

N-(3-oxopropyl)benzene sulfonamide