Androst-5-en-16-one, 3,7,17-trihydroxy-, (3beta,7alpha,17alpha)- (9CI)

Base Information

• Chemical Name: Androst-5-en-16-one, 3,7,17-trihydroxy-, (3beta,7alpha,17alpha)- (9CI)
• CAS No.: 207670-07-3
• Molecular Formula: C₁₉H₂₈O₄
• Molecular Weight: 320.429
• Mol file: 207670-07-3.mol

Synonyms:Androst-5-en-16-one, 3,7,17-trihydroxy-, (3beta,7alpha,17alpha)- (9CI)

Chemical Property of Androst-5-en-16-one, 3,7,17-trihydroxy-, (3beta,7alpha,17alpha)- (9CI)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Androst-5-en-16-one, 3,7,17-trihydroxy-, (3beta,7alpha,17alpha)- (9CI)

There total 5 articles about Androst-5-en-16-one, 3,7,17-trihydroxy-, (3beta,7alpha,17alpha)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

16α-hydroxy dehydroepiandrosterone (1232-73-1) → 3β,7α,17β-trihydroxyandrost-5-en-16-one (165181-92-0,207670-07-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 67 percent / pyridine / 12 h / Ambient temperature

2: NaHCO₃, dibromomantin / hexane / 0.5 h / Heating

3: LiBr / toluene; acetone

4: silver acetate / CH₂Cl₂; acetone / 0.5 h

5: K₂CO₃ / methanol / 2 h / Ambient temperature

With pyridine; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; silver(I) acetate; sodium hydrogencarbonate; potassium carbonate; lithium bromide; In methanol; hexane; dichloromethane; acetone; toluene;

DOI:10.1016/S0039-128X(97)00159-1

Reference yield:

17-oxoandrost-5-ene-3β,16α-diyl diacetate (10587-75-4) → 3β,7α,17β-trihydroxyandrost-5-en-16-one (165181-92-0,207670-07-3)

Guidance literature:

Multi-step reaction with 4 steps

1: NaHCO₃, dibromomantin / hexane / 0.5 h / Heating

2: LiBr / toluene; acetone

3: silver acetate / CH₂Cl₂; acetone / 0.5 h

4: K₂CO₃ / methanol / 2 h / Ambient temperature

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; silver(I) acetate; sodium hydrogencarbonate; potassium carbonate; lithium bromide; In methanol; hexane; dichloromethane; acetone; toluene;

DOI:10.1016/S0039-128X(97)00159-1

Reference yield:

Acetic acid (3S,8R,9S,10R,13S,14S,16R)-16-acetoxy-7-bromo-10,13-dimethyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester → 3β,7α,17β-trihydroxyandrost-5-en-16-one (165181-92-0,207670-07-3)

Guidance literature:

Multi-step reaction with 3 steps

1: LiBr / toluene; acetone

2: silver acetate / CH₂Cl₂; acetone / 0.5 h

3: K₂CO₃ / methanol / 2 h / Ambient temperature

With silver(I) acetate; potassium carbonate; lithium bromide; In methanol; dichloromethane; acetone; toluene;

DOI:10.1016/S0039-128X(97)00159-1

upstream raw materials:

3β,16α-diacetoxy-7α-hydroxy-androst-5-en-17-one

16α-hydroxy dehydroepiandrosterone

17-oxoandrost-5-ene-3β,16α-diyl diacetate

Acetic acid (3S,7S,8R,9S,10R,13S,14S,16R)-16-acetoxy-7-bromo-10,13-dimethyl-17-oxo-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester