Ethanone, 1-(2-amino-5-methylphenyl)- (9CI)

Base Information

• Chemical Name: Ethanone, 1-(2-amino-5-methylphenyl)- (9CI)
• CAS No.: 25428-06-2
• Molecular Formula: C9H11 N O
• Molecular Weight: 149.192
• Hs Code.: 2922399090
• Mol file: 25428-06-2.mol

Synonyms:Acetophenone,2'-amino-5'-methyl- (6CI,8CI); 2'-Amino-5'-methylacetophenone

Chemical Property of Ethanone, 1-(2-amino-5-methylphenyl)- (9CI)

Chemical Property:

• PSA: 43.09000
• LogP: 2.36100

Purity/Quality:

99% ^*data from raw suppliers

1-(2-Amino-5-methyl-phenyl)-ethanone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethanone, 1-(2-amino-5-methylphenyl)- (9CI)

There total 17 articles about Ethanone, 1-(2-amino-5-methylphenyl)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-(2-acetyl-4-methylphenyl)-4-methylbenzenesulfonamide (1438400-35-1) → 2-amino-5-methyl-acetophenone (25428-06-2)

Guidance literature:

N-(2-acetyl-4-methylphenyl)-4-methylbenzenesulfonamide; With sulfuric acid; at 0 - 20 ℃; for 2h; Inert atmosphere; Schlenk technique;

With sodium hydrogencarbonate; Inert atmosphere; Schlenk technique;

DOI:10.1039/c3cc41915k

Reference yield: 99.0%

4-Methylacetanilide (103-89-9) → 2-amino-5-methyl-acetophenone (25428-06-2)

Guidance literature:

With cetyltrimethylammonim bromide; In water; at 25 ℃; Reagent/catalyst; Solvent; regioselective reaction; Irradiation; Micellar solution; Inert atmosphere;

DOI:10.1039/c5pp00349k

Reference yield: 99.0%

2-Amino-5-methylbenzoic acid (2941-78-8) + methyllithium (917-54-4) → 2-amino-5-methyl-acetophenone (25428-06-2)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 6h;

DOI:10.1002/chem.201203993

upstream raw materials:

4-Methylacetanilide

N-(4-chlorophenyl)propionamide

1-(5-methyl-2-nitrophenyl)-ethanone

2,3,5-trimethyl-1H-indole

Downstream raw materials:

N-(2-acetyl-4-methylphenyl)acetamide

2-Acetylamino-5-acetoxymethyl-acetophenon

N-(2-acetyl-4-methylphenyl)-5'-bromo-2'-methoxybenzamide

2-(4-fluorophenyl)-3,5-dimethyl-2H-indazole