3-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)propanoic acid

Base Information

Chemical Name:3-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)propanoic acid
CAS No.:1044870-77-0
Molecular Formula:C₁₉H₁₈N₂O₅
Molecular Weight:354.362
Hs Code.:

Synonyms:3-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)propanoic acid

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Chemical Property of 3-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)propanoic acid

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Technology Process of 3-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)propanoic acid

There total 6 articles about 3-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1044872-26-5
3-[4-(5,7-dimethoxy-4-oxo-3,4-dihydro-quinazolin-2-yl)-phenyl]-propionic acid ethyl ester

: 1044870-77-0
3-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)propanoic acid

Guidance literature:: 3-[4-(5,7-dimethoxy-4-oxo-3,4-dihydro-quinazolin-2-yl)-phenyl]-propionic acid ethyl ester; With potassium hydroxide; water; In tetrahydrofuran; methanol; water; at 20 ℃; for 16h;

With hydrogenchloride; In water;

Reference yield:

: 15164-44-0
p-(iodophenyl)carboxaldehyde

: 1044870-77-0
3-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; tetrabutyl-ammonium chloride; palladium diacetate / N,N-dimethyl-formamide / 16 h / 90 °C

2: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 16 h / 155 °C

3: potassium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

With tetrabutyl-ammonium chloride; water; palladium diacetate; toluene-4-sulfonic acid; sodium hydrogensulfite; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 21544-81-0
4,6-dimethoxyindoline-2,3-dione

: 1044870-77-0
3-(4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; dihydrogen peroxide / tetrahydrofuran; water / 70 °C

1.2: 3 h / 20 °C

1.3: 16 h / 20 °C

2.1: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 16 h / 155 °C

3.1: potassium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

With water; dihydrogen peroxide; toluene-4-sulfonic acid; sodium hydrogensulfite; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; water;