1-(3,4-difluorobenzyl)-N-(3-isopropoxy-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide trifluoroacetic acid salt

Base Information

• Chemical Name: 1-(3,4-difluorobenzyl)-N-(3-isopropoxy-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide trifluoroacetic acid salt
• CAS No.: 1001412-13-0
• Molecular Formula: C₂HF₃O₂*C₃₀H₂₆F₂N₄O₃
• Molecular Weight: 642.582
• Mol file: 1001412-13-0.mol

Synonyms:1-(3,4-difluorobenzyl)-N-(3-isopropoxy-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide trifluoroacetic acid salt

Chemical Property of 1-(3,4-difluorobenzyl)-N-(3-isopropoxy-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide trifluoroacetic acid salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(3,4-difluorobenzyl)-N-(3-isopropoxy-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide trifluoroacetic acid salt

There total 11 articles about 1-(3,4-difluorobenzyl)-N-(3-isopropoxy-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

1-(3,4-difluorobenzyl)-N-(3-isopropoxy-5-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (1001414-27-2) → 1-(3,4-difluorobenzyl)-N-(3-isopropoxy-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide trifluoroacetic acid salt (1001412-13-0)

Guidance literature:

With potassium carbonate; In methanol; for 0.5h; Heating / reflux;

Reference yield:

3-bromo-1-(benzenesulfonyl)-1H-pyrrolo [2,3-b]pyridine (880769-95-9) → 1-(3,4-difluorobenzyl)-N-(3-isopropoxy-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide trifluoroacetic acid salt (1001412-13-0)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 0.25 h / 120 °C / Microwave on 50 watts

2: hydroxylamine hydrochloride / methanol

3: acetic acid; zinc / 100 °C / Heating / reflux

4: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

5: potassium carbonate / methanol / 0.5 h / Heating / reflux

With hydroxylamine hydrochloride; sodium hydrogencarbonate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In methanol; water; N,N-dimethyl-formamide; 1: Suzuki Coupling;

Reference yield:

7-Azaindole (271-63-6) → 1-(3,4-difluorobenzyl)-N-(3-isopropoxy-5-(1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide trifluoroacetic acid salt (1001412-13-0)

Guidance literature:

Multi-step reaction with 7 steps

1.1: dichloromethane / 0 °C

2.1: N-Bromosuccinimide; potassium carbonate / tetrahydrofuran / 0 °C

2.2: 20 °C

3.1: sodium hydrogencarbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; N,N-dimethyl-formamide / 0.25 h / 120 °C / Microwave on 50 watts

4.1: hydroxylamine hydrochloride / methanol

5.1: acetic acid; zinc / 100 °C / Heating / reflux

6.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 1 h

7.1: potassium carbonate / methanol / 0.5 h / Heating / reflux

With N-Bromosuccinimide; hydroxylamine hydrochloride; sodium hydrogencarbonate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; zinc; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; 3.1: Suzuki Coupling;

upstream raw materials:

1-(3,4-difluorobenzyl)-N-(3-isopropoxy-5-(1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)benzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide

3-bromo-1-(benzenesulfonyl)-1H-pyrrolo [2,3-b]pyridine

7-Azaindole

1-(3,4-difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid

Refernces