(2R,5S)-5-(3,4-difluorophenyl)pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

Base Information

Chemical Name:(2R,5S)-5-(3,4-difluorophenyl)pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester
CAS No.:937814-40-9
Molecular Formula:C₁₈H₂₃F₂NO₄
Molecular Weight:355.382
Hs Code.:

Synonyms:(2R,5S)-5-(3,4-difluorophenyl)pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

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Chemical Property of (2R,5S)-5-(3,4-difluorophenyl)pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

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Technology Process of (2R,5S)-5-(3,4-difluorophenyl)pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

There total 8 articles about (2R,5S)-5-(3,4-difluorophenyl)pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68766-96-1
ethyl (R)-2-pyrrolidone-5-carboxylate

: 937814-40-9
(2R,5S)-5-(3,4-difluorophenyl)pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dmap / tetrahydrofuran / 5 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: tetrahydrofuran / 1 h / -40 °C

3.1: hydrogenchloride / ethyl acetate / 3 h / 20 °C

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 31 h / 20 °C

5.1: triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C

5.2: 0.33 h / 20 °C

With hydrogenchloride; hydrogen; triethylamine; dmap; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 937814-39-6
(R)-2-t-butoxycarbonylamino-5-oxo-5-(3,4-difluorophenyl)valeric acid ethyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 937814-40-9
(2R,5S)-5-(3,4-difluorophenyl)pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

Guidance literature:: (R)-2-t-butoxycarbonylamino-5-oxo-5-(3,4-difluorophenyl)valeric acid ethyl ester; With hydrogenchloride; In ethyl acetate; at 20 ℃; for 16h;

With water; sodium hydrogencarbonate; In ethyl acetate;

di-tert-butyl dicarbonate; With hydrogen; triethylamine; palladium 10% on activated carbon; more than 3 stages;

Reference yield:

: 1050394-01-8
(2R,5S)-5-(3,4-difluorophenyl)pyrrolidine-2-carboxylic acid ethyl ester

: 24424-99-5
di-tert-butyl dicarbonate

: 937814-40-9
(2R,5S)-5-(3,4-difluorophenyl)pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

Guidance literature:: (2R,5S)-5-(3,4-difluorophenyl)pyrrolidine-2-carboxylic acid ethyl ester; di-tert-butyl dicarbonate; With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 5h;

With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;