(R)-2-t-butoxycarbonylamino-5-oxo-5-(3,4-difluorophenyl)valeric acid ethyl ester

Base Information

Chemical Name:(R)-2-t-butoxycarbonylamino-5-oxo-5-(3,4-difluorophenyl)valeric acid ethyl ester
CAS No.:937814-39-6
Molecular Formula:C₁₈H₂₃F₂NO₅
Molecular Weight:371.381
Hs Code.:

Synonyms:(R)-2-t-butoxycarbonylamino-5-oxo-5-(3,4-difluorophenyl)valeric acid ethyl ester

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Chemical Property of (R)-2-t-butoxycarbonylamino-5-oxo-5-(3,4-difluorophenyl)valeric acid ethyl ester

Chemical Property:

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Technology Process of (R)-2-t-butoxycarbonylamino-5-oxo-5-(3,4-difluorophenyl)valeric acid ethyl ester

There total 4 articles about (R)-2-t-butoxycarbonylamino-5-oxo-5-(3,4-difluorophenyl)valeric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68766-96-1
ethyl (R)-2-pyrrolidone-5-carboxylate

: 937814-39-6
(R)-2-t-butoxycarbonylamino-5-oxo-5-(3,4-difluorophenyl)valeric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dmap / tetrahydrofuran / 5 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: tetrahydrofuran / 1 h / -40 °C

With triethylamine; dmap; In tetrahydrofuran;

Reference yield:

: 90897-92-0
3,4-difluorophenylmagnesium bromide

: 144978-12-1,128811-48-3,144978-35-8,251924-83-1
1-tert-butyl 2-ethyl (2R)-5-oxopyrrolidine-1,2-dicarboxylate

: 937814-39-6
(R)-2-t-butoxycarbonylamino-5-oxo-5-(3,4-difluorophenyl)valeric acid ethyl ester

Guidance literature:: In tetrahydrofuran; at -78 - -40 ℃; for 3h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 937814-39-6
(R)-2-t-butoxycarbonylamino-5-oxo-5-(3,4-difluorophenyl)valeric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dmap / tetrahydrofuran / 5 h / 20 °C

1.2: 0.5 h / 20 °C

2.1: tetrahydrofuran / 1 h / -40 °C

With triethylamine; dmap; In tetrahydrofuran;