1-[6-(2-t-Butylsulfamoylphenyl)pyridin-3-ylmethyl]-5-propyl-1H-pyrazole-3-carboxylic acid

Base Information

Chemical Name:1-[6-(2-t-Butylsulfamoylphenyl)pyridin-3-ylmethyl]-5-propyl-1H-pyrazole-3-carboxylic acid
CAS No.:1260232-69-6
Molecular Formula:C₂₃H₂₈N₄O₄S
Molecular Weight:456.566
Hs Code.:

Synonyms:1-[6-(2-t-Butylsulfamoylphenyl)pyridin-3-ylmethyl]-5-propyl-1H-pyrazole-3-carboxylic acid

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Chemical Property of 1-[6-(2-t-Butylsulfamoylphenyl)pyridin-3-ylmethyl]-5-propyl-1H-pyrazole-3-carboxylic acid

Chemical Property:

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Technology Process of 1-[6-(2-t-Butylsulfamoylphenyl)pyridin-3-ylmethyl]-5-propyl-1H-pyrazole-3-carboxylic acid

There total 1 articles about 1-[6-(2-t-Butylsulfamoylphenyl)pyridin-3-ylmethyl]-5-propyl-1H-pyrazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1260231-89-7
N-(t-butyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)benzenesulfonamide

: 1260232-69-6
1-[6-(2-t-Butylsulfamoylphenyl)pyridin-3-ylmethyl]-5-propyl-1H-pyrazole-3-carboxylic acid

Guidance literature:: N-(t-butyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolane-2-yl)benzenesulfonamide; With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; at 100 ℃; for 0.5h; Microwave irradiation; Inert atmosphere;

With water; lithium hydroxide; In tert-butyl alcohol;

With hydrogenchloride; In water; pH=4 - 5;

Reference yield:

: 1260232-69-6
1-[6-(2-t-Butylsulfamoylphenyl)pyridin-3-ylmethyl]-5-propyl-1H-pyrazole-3-carboxylic acid

: 108-24-7
acetic anhydride

: 1260232-68-5
1-[6-(2-acetylsulfamoylphenyl)pyridin-3-ylmethyl]-5-propyl-1H-pyrazole-3-carboxylic acid

Guidance literature:: 1-[6-(2-t-Butylsulfamoylphenyl)pyridin-3-ylmethyl]-5-propyl-1H-pyrazole-3-carboxylic acid; With trifluoroacetic acid; at 40 ℃; for 3h; Neat (no solvent);

acetic anhydride; With triethylamine; In dichloromethane; at 20 ℃;

Reference yield:

: 1260232-69-6
1-[6-(2-t-Butylsulfamoylphenyl)pyridin-3-ylmethyl]-5-propyl-1H-pyrazole-3-carboxylic acid

: 76-05-1
trifluoroacetic acid

: (2R,3R)-3-amino-2-hydroxy-4-phenylbutyric acid hydrochloride

: (2R,3R)-3-({1-[6-(2-acetylsulfamoylphenyl)pyridin-3-ylmethyl]-5-propyl-1H-pyrazole-3-carbonyl}amino)-2-hydroxy-4-phenylbutyric acid trifluoroacetate

Guidance literature:: 1-[6-(2-t-Butylsulfamoylphenyl)pyridin-3-ylmethyl]-5-propyl-1H-pyrazole-3-carboxylic acid; With HATU; In N,N-dimethyl-formamide; for 0.0833333h;

(2R,3R)-3-amino-2-hydroxy-4-phenylbutyric acid hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 40 ℃;

trifluoroacetic acid; In water; acetonitrile;