Technology Process of C28H23N3O2S
There total 7 articles about C28H23N3O2S which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-(tert-butyl)-3,4-dihydro-9-[4-(4-propargyloxymethyl)benzoylphenyl]-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine;
With
trifluoroacetic acid;
In
chloroform;
for 1h;
Molecular sieve;
Reflux;
With
triethylamine;
In
chloroform;
at 0 ℃;
pH=8 - 9;
Molecular sieve;
DOI:10.1016/j.bmc.2013.01.016
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C
2.1: triethylamine; dmap / dichloromethane / 3 h / 20 °C
3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.93 h / -78 °C / Inert atmosphere
3.2: 1 h / -78 - 20 °C / Inert atmosphere
4.1: tetrakis(triphenylphosphine) palladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate / toluene; ethanol; water / 1 h / Reflux
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C
6.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
6.2: 0 - 20 °C
7.1: trifluoroacetic acid / chloroform / 1 h / Molecular sieve; Reflux
7.2: 0 °C / pH 8 - 9 / Molecular sieve
With
dmap; tetrakis(triphenylphosphine) palladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; tetrabutyl ammonium fluoride; tert.-butyl lithium; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene; mineral oil; pentane;
4.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2013.01.016
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrakis(triphenylphosphine) palladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate / toluene; ethanol; water / 1 h / Reflux
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 2 h / 20 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C
3.2: 0 - 20 °C
4.1: trifluoroacetic acid / chloroform / 1 h / Molecular sieve; Reflux
4.2: 0 °C / pH 8 - 9 / Molecular sieve
With
tetrakis(triphenylphosphine) palladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; tetrabutyl ammonium fluoride; sodium hydride; potassium carbonate; trifluoroacetic acid;
In
tetrahydrofuran; ethanol; chloroform; water; toluene; mineral oil;
1.1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2013.01.016
![N-(tert-butyl)-3,4-dihydro-9-[4-(4-propargyloxymethyl)benzoylphenyl]-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine](/Databaselist/images/loading.webp)
