(S)‐5‐benzyl‐3‐(2‐hydroxyethyl)‐2,2dimethylimidazolidin‐4‐one hydrochloride

Base Information

Chemical Name:(S)‐5‐benzyl‐3‐(2‐hydroxyethyl)‐2,2dimethylimidazolidin‐4‐one hydrochloride
CAS No.:1214907-89-7
Molecular Formula:C₁₄H₂₀N₂O₂*ClH
Molecular Weight:284.786
Hs Code.:

Synonyms:(S)‐5‐benzyl‐3‐(2‐hydroxyethyl)‐2,2dimethylimidazolidin‐4‐one hydrochloride

Suppliers and Price of (S)‐5‐benzyl‐3‐(2‐hydroxyethyl)‐2,2dimethylimidazolidin‐4‐one hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of (S)‐5‐benzyl‐3‐(2‐hydroxyethyl)‐2,2dimethylimidazolidin‐4‐one hydrochloride

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of (S)‐5‐benzyl‐3‐(2‐hydroxyethyl)‐2,2dimethylimidazolidin‐4‐one hydrochloride

There total 3 articles about (S)‐5‐benzyl‐3‐(2‐hydroxyethyl)‐2,2dimethylimidazolidin‐4‐one hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 75991-52-5
(S)‐2‐amino‐N‐(2‐hydroxyethyl)‐3‐phenylpropanamide

: 67-64-1
acetone

: 1214907-89-7
(S)‐5‐benzyl‐3‐(2‐hydroxyethyl)‐2,2dimethylimidazolidin‐4‐one hydrochloride

Guidance literature:: (S)‐2‐amino‐N‐(2‐hydroxyethyl)‐3‐phenylpropanamide; acetone; With toluene-4-sulfonic acid; In isopropyl alcohol; at 85 ℃; for 5.33333h;

With hydrogenchloride; In methanol;
DOI:10.1021/jo902585j

Reference yield:

: 63-91-2,25191-15-5,658-69-5,67675-33-6
L-phenylalanine

: 1214907-89-7
(S)‐5‐benzyl‐3‐(2‐hydroxyethyl)‐2,2dimethylimidazolidin‐4‐one hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: thionyl chloride / 24 h / 0 - 20 °C

2.1: 12 h / 20 °C

3.1: toluene-4-sulfonic acid / isopropyl alcohol / 12 h / Reflux; Inert atmosphere; Dean-Stark

3.2: 1 h / 20 °C / Cooling with ice

With thionyl chloride; toluene-4-sulfonic acid; In isopropyl alcohol;
DOI:10.1002/cctc.201901129

Reference yield:

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 1214907-89-7
(S)‐5‐benzyl‐3‐(2‐hydroxyethyl)‐2,2dimethylimidazolidin‐4‐one hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: 12 h / 20 °C

2.1: toluene-4-sulfonic acid / isopropyl alcohol / 12 h / Reflux; Inert atmosphere; Dean-Stark

2.2: 1 h / 20 °C / Cooling with ice

With toluene-4-sulfonic acid; In isopropyl alcohol;
DOI:10.1002/cctc.201901129