methyl 3-[6-(dimethylsulfamoyl)-1,2,3,4-tetrahydroquinolin-1-yl]-2-(4-fluorophenyl)quinoxaline-6-carboxylate

Base Information

Chemical Name:methyl 3-[6-(dimethylsulfamoyl)-1,2,3,4-tetrahydroquinolin-1-yl]-2-(4-fluorophenyl)quinoxaline-6-carboxylate
CAS No.:1384850-62-7
Molecular Formula:C₂₇H₂₅FN₄O₄S
Molecular Weight:520.584
Hs Code.:

Synonyms:methyl 3-[6-(dimethylsulfamoyl)-1,2,3,4-tetrahydroquinolin-1-yl]-2-(4-fluorophenyl)quinoxaline-6-carboxylate

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Chemical Property of methyl 3-[6-(dimethylsulfamoyl)-1,2,3,4-tetrahydroquinolin-1-yl]-2-(4-fluorophenyl)quinoxaline-6-carboxylate

Chemical Property:

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Technology Process of methyl 3-[6-(dimethylsulfamoyl)-1,2,3,4-tetrahydroquinolin-1-yl]-2-(4-fluorophenyl)quinoxaline-6-carboxylate

There total 12 articles about methyl 3-[6-(dimethylsulfamoyl)-1,2,3,4-tetrahydroquinolin-1-yl]-2-(4-fluorophenyl)quinoxaline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1384850-61-6
methyl 3-[6-(chlorosulfonyl)-1,2,3,4-tetrahydroquinolin-1-yl]-2-(4-fluorophenyl)quinoxaline-6-carboxylate

: 506-59-2
N,N-dimethylammonium chloride

: 1384850-62-7
methyl 3-[6-(dimethylsulfamoyl)-1,2,3,4-tetrahydroquinolin-1-yl]-2-(4-fluorophenyl)quinoxaline-6-carboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

Reference yield:

: 1384850-41-2
methyl 3-(1,2,3,4-tetrahydroquinolin-1(2H)-yl)-2-(trifluoromethylsulfonyloxy) quinoxaline-6-carboxylate

: 1384850-62-7
methyl 3-[6-(dimethylsulfamoyl)-1,2,3,4-tetrahydroquinolin-1-yl]-2-(4-fluorophenyl)quinoxaline-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 95 °C / Inert atmosphere

2: thionyl chloride; sulfuric acid / chloroform / 3 h / 85 °C

3: triethylamine / dichloromethane / 0.5 h / 20 °C

With potassium phosphate; thionyl chloride; sulfuric acid; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; chloroform; water;

Reference yield:

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 1384850-62-7
methyl 3-[6-(dimethylsulfamoyl)-1,2,3,4-tetrahydroquinolin-1-yl]-2-(4-fluorophenyl)quinoxaline-6-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 20 °C

2.1: hydrogen / palladium on activated charcoal / methanol / 0.5 h / 20 °C

3.1: 3 h / Reflux

4.1: trichlorophosphate; N,N-dimethyl-aniline / toluene / 110 °C

5.1: sulfuric acid / 20 °C

5.2: pH 7

6.1: 3 h / 150 °C

7.1: pyridine / dichloromethane / 20 °C

8.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 95 °C / Inert atmosphere

9.1: thionyl chloride; sulfuric acid / chloroform / 3 h / 85 °C

10.1: triethylamine / dichloromethane / 0.5 h / 20 °C

With pyridine; potassium phosphate; thionyl chloride; sulfuric acid; hydrogen; N,N-dimethyl-aniline; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene;