(2S,5S)-7-methyl-6-oxo-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]nonane

Base Information

Chemical Name:(2S,5S)-7-methyl-6-oxo-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]nonane
CAS No.:1444536-27-9
Molecular Formula:C₂₀H₂₀F₃N₃O₂
Molecular Weight:391.393
Hs Code.:

Synonyms:(2S,5S)-7-methyl-6-oxo-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]nonane

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Chemical Property of (2S,5S)-7-methyl-6-oxo-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]nonane

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Technology Process of (2S,5S)-7-methyl-6-oxo-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]nonane

There total 13 articles about (2S,5S)-7-methyl-6-oxo-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]nonane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1444536-03-1
(5S)-7-methyl-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]non-1-en-6-one

: 1444536-39-3
(2R,5S)-7-methyl-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]nonan-6-one

: 1444536-27-9
(2S,5S)-7-methyl-6-oxo-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]nonane

Guidance literature:: With hydrogenchloride; sodium tris(acetoxy)borohydride; In dichloromethane; water; at 0 ℃; for 18h;

Reference yield:

: 1444536-15-5
tert-butyl (2S,5S)-7-methyl-6-oxo-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]nonane-1-carboxylate

: 1444536-27-9
(2S,5S)-7-methyl-6-oxo-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]nonane

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1444535-16-3
3-(benzhydrylidene amino)-1-methyl pyrrolidin-2-one

: 1444536-27-9
(2S,5S)-7-methyl-6-oxo-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]nonane

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium tert-butylate / tetrahydrofuran; toluene / 3.5 h / -65 °C / Molecular sieve; Inert atmosphere

2.1: citric acid / tetrahydrofuran / 18 h / 20 °C

2.2: Ambersep 900(OH) / 1.5 h / 20 °C

3.1: isopropyl alcohol / 3.5 h / 55 - 75 °C

3.2: ambersep-900(OH) / 1 h

4.1: dichloromethane / 5 h / 40 °C

5.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / tetrahydrofuran / 90 h / 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane; water / 20 °C

7.1: silver trifluoromethanesulfonate / acetonitrile / 42 h / 40 °C

8.1: N-tert-butylaminoborane / dichloromethane / 1.67 h / -78 - -70 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; N-tert-butylaminoborane; potassium tert-butylate; silver trifluoromethanesulfonate; diethylamine; trifluoroacetic acid; citric acid; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; toluene; acetonitrile;