(5S)-7-methyl-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]non-1-en-6-one

Base Information

Chemical Name:(5S)-7-methyl-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]non-1-en-6-one
CAS No.:1444536-03-1
Molecular Formula:C₂₀H₁₈F₃N₃O₂
Molecular Weight:389.377
Hs Code.:

Synonyms:(5S)-7-methyl-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]non-1-en-6-one

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Chemical Property of (5S)-7-methyl-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]non-1-en-6-one

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Technology Process of (5S)-7-methyl-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]non-1-en-6-one

There total 10 articles about (5S)-7-methyl-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]non-1-en-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.1%

: 1444535-97-0
(3S)-3-amino-1-methyl-3-[3-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]prop-2-ynyl]pyrrolidin-2-one

: 1444536-03-1
(5S)-7-methyl-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]non-1-en-6-one

Guidance literature:: With silver trifluoromethanesulfonate; In acetonitrile; at 40 ℃; for 42h;

Reference yield:

: 1444535-16-3
3-(benzhydrylidene amino)-1-methyl pyrrolidin-2-one

: 1444536-03-1
(5S)-7-methyl-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]non-1-en-6-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate / tetrahydrofuran; toluene / 3.5 h / -65 °C / Molecular sieve; Inert atmosphere

2.1: citric acid / tetrahydrofuran / 18 h / 20 °C

2.2: Ambersep 900(OH) / 1.5 h / 20 °C

3.1: isopropyl alcohol / 3.5 h / 55 - 75 °C

3.2: ambersep-900(OH) / 1 h

4.1: dichloromethane / 5 h / 40 °C

5.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / tetrahydrofuran / 90 h / 20 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane; water / 20 °C

7.1: silver trifluoromethanesulfonate / acetonitrile / 42 h / 40 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium tert-butylate; silver trifluoromethanesulfonate; diethylamine; trifluoroacetic acid; citric acid; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; toluene; acetonitrile;

Reference yield:

: 1444535-27-6
3-(benzhydrylideneamino)-1-methyl-3-(prop-2-ynyl)pyrrolidin-2-one

: 1444536-03-1
(5S)-7-methyl-2-[4-[3-(trifluoromethoxy)phenyl]-2-pyridyl]-1,7-diazaspiro[4.4]non-1-en-6-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: citric acid / tetrahydrofuran / 18 h / 20 °C

1.2: Ambersep 900(OH) / 1.5 h / 20 °C

2.1: isopropyl alcohol / 3.5 h / 55 - 75 °C

2.2: ambersep-900(OH) / 1 h

3.1: dichloromethane / 5 h / 40 °C

4.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; diethylamine / tetrahydrofuran / 90 h / 20 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane; water / 20 °C

6.1: silver trifluoromethanesulfonate / acetonitrile / 42 h / 40 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; silver trifluoromethanesulfonate; diethylamine; trifluoroacetic acid; citric acid; In tetrahydrofuran; dichloromethane; water; isopropyl alcohol; acetonitrile;