tert-butyl N-[4-amino-2-(trifluoromethyl)phenyl]-N-tert-butoxycarbonylcarbamate

Base Information

Chemical Name:tert-butyl N-[4-amino-2-(trifluoromethyl)phenyl]-N-tert-butoxycarbonylcarbamate
CAS No.:1089725-60-9
Molecular Formula:C₁₇H₂₃F₃N₂O₄
Molecular Weight:376.376
Hs Code.:

Synonyms:tert-butyl N-[4-amino-2-(trifluoromethyl)phenyl]-N-tert-butoxycarbonylcarbamate

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Chemical Property of tert-butyl N-[4-amino-2-(trifluoromethyl)phenyl]-N-tert-butoxycarbonylcarbamate

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Technology Process of tert-butyl N-[4-amino-2-(trifluoromethyl)phenyl]-N-tert-butoxycarbonylcarbamate

There total 4 articles about tert-butyl N-[4-amino-2-(trifluoromethyl)phenyl]-N-tert-butoxycarbonylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.6%

: 1089725-58-5
tert-butyl N-tert-butoxycarbonyl-N-[4-nitro-2-(trifluoromethyl)phenyl]carbamate

: 1089725-60-9
tert-butyl N-[4-amino-2-(trifluoromethyl)phenyl]-N-tert-butoxycarbonylcarbamate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 12h;

Reference yield: 38.0%

: 1089725-60-9
tert-butyl N-[4-amino-2-(trifluoromethyl)phenyl]-N-tert-butoxycarbonylcarbamate

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In ethyl acetate; at 20 - 24 ℃;

Reference yield:

: 121-01-7
4-nitro-2-trifluoromethyl-aniline

: 1089725-60-9
tert-butyl N-[4-amino-2-(trifluoromethyl)phenyl]-N-tert-butoxycarbonylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap / tetrahydrofuran / 20 °C

2: hydrogen; palladium on activated charcoal / ethanol / 20 °C

With dmap; palladium on activated charcoal; hydrogen; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2015.10.013