4-(4-(3-(4-amino-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide

Base Information

Chemical Name:4-(4-(3-(4-amino-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide
CAS No.:1215081-95-0
Molecular Formula:C₂₁H₁₈F₃N₅O₃
Molecular Weight:445.401
Hs Code.:

Synonyms:4-(4-(3-(4-amino-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(4-(3-(4-amino-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide

Chemical Property:

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Technology Process of 4-(4-(3-(4-amino-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide

There total 5 articles about 4-(4-(3-(4-amino-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-44-5
phosgene

: 284462-37-9
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide

: iminodicarbonate

: 1215081-95-0
4-(4-(3-(4-amino-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide

Guidance literature:: With triethylamine; In toluene;

Reference yield:

: 1089725-58-5
tert-butyl N-tert-butoxycarbonyl-N-[4-nitro-2-(trifluoromethyl)phenyl]carbamate

: 1215081-95-0
4-(4-(3-(4-amino-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid; iron / methanol / 2 h / 70 °C / Inert atmosphere

2.1: triethylamine / toluene / 16 h / Reflux

2.2: 2 h / 20 °C / Reflux

3.1: trifluoroacetic acid

With iron; acetic acid; triethylamine; trifluoroacetic acid; In methanol; toluene;

Reference yield:

: 1089725-60-9
tert-butyl N-[4-amino-2-(trifluoromethyl)phenyl]-N-tert-butoxycarbonylcarbamate

: 1215081-95-0
4-(4-(3-(4-amino-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / toluene / 16 h / Reflux

1.2: 2 h / 20 °C / Reflux

2.1: trifluoroacetic acid

With triethylamine; trifluoroacetic acid; In toluene;