3-(4-aminophenyl)-1H-pyrrolo[3,2-b]pyridine-2-carboxamide

Base Information

Chemical Name:3-(4-aminophenyl)-1H-pyrrolo[3,2-b]pyridine-2-carboxamide
CAS No.:890434-90-9
Molecular Formula:C₁₄H₁₂N₄O
Molecular Weight:252.275
Hs Code.:

Synonyms:3-(4-aminophenyl)-1H-pyrrolo[3,2-b]pyridine-2-carboxamide

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Chemical Property of 3-(4-aminophenyl)-1H-pyrrolo[3,2-b]pyridine-2-carboxamide

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Technology Process of 3-(4-aminophenyl)-1H-pyrrolo[3,2-b]pyridine-2-carboxamide

There total 6 articles about 3-(4-aminophenyl)-1H-pyrrolo[3,2-b]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1237742-36-7
3-(4-nitrophenyl)-1H-pyrrolo[3,2-b]pyridine-2-carboxamide

: 890434-90-9
3-(4-aminophenyl)-1H-pyrrolo[3,2-b]pyridine-2-carboxamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; at 22 ℃; for 3.5h; under 1500.15 Torr;

Reference yield:

: 18699-87-1
2-methyl-3-nitropyridine

: 890434-90-9
3-(4-aminophenyl)-1H-pyrrolo[3,2-b]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 15 h

2: hydrogen / palladium 10% on activated carbon / ethanol / 3 h / 20 °C / 1500.15 Torr

3: pyridine; pyridinium hydrobromide perbromide / 0.25 h / 50 °C

4: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 20 h / Heating / reflux

5: ammonia / methanol / 16 h / 100 °C

6: hydrogen / palladium 10% on activated carbon / methanol / 3.5 h / 22 °C / 1500.15 Torr

With pyridine; pyridinium hydrobromide perbromide; ammonia; hydrogen; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; methanol; ethanol; 4: Suzuki Coupling;

Reference yield:

: 889658-85-9
ethyl 3-bromo-1H-pyrrolo[3,2-b]pyridine-2-carboxylate

: 890434-90-9
3-(4-aminophenyl)-1H-pyrrolo[3,2-b]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 20 h / Heating / reflux

2: ammonia / methanol / 16 h / 100 °C

3: hydrogen / palladium 10% on activated carbon / methanol / 3.5 h / 22 °C / 1500.15 Torr

With ammonia; hydrogen; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; In 1,4-dioxane; methanol; 1: Suzuki Coupling;