2-[3-[2-[benzyloxycarbonyl-[4-(pyridin-3-yl)butyl]amino]ethyl]-2-(3,5-dimethylphenyl)-1H-indol-5-yl]-2-methylpropionic acid

Base Information

Chemical Name:2-[3-[2-[benzyloxycarbonyl-[4-(pyridin-3-yl)butyl]amino]ethyl]-2-(3,5-dimethylphenyl)-1H-indol-5-yl]-2-methylpropionic acid
CAS No.:192643-88-2
Molecular Formula:C₃₉H₄₃N₃O₄
Molecular Weight:617.788
Hs Code.:

Synonyms:2-[3-[2-[benzyloxycarbonyl-[4-(pyridin-3-yl)butyl]amino]ethyl]-2-(3,5-dimethylphenyl)-1H-indol-5-yl]-2-methylpropionic acid

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Chemical Property of 2-[3-[2-[benzyloxycarbonyl-[4-(pyridin-3-yl)butyl]amino]ethyl]-2-(3,5-dimethylphenyl)-1H-indol-5-yl]-2-methylpropionic acid

Chemical Property:

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Technology Process of 2-[3-[2-[benzyloxycarbonyl-[4-(pyridin-3-yl)butyl]amino]ethyl]-2-(3,5-dimethylphenyl)-1H-indol-5-yl]-2-methylpropionic acid

There total 6 articles about 2-[3-[2-[benzyloxycarbonyl-[4-(pyridin-3-yl)butyl]amino]ethyl]-2-(3,5-dimethylphenyl)-1H-indol-5-yl]-2-methylpropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7732-18-5
water

: 192643-87-1
2-[3-[2-[benzyloxycarbonyl-[4-(pyridin-3-yl)butyl]amino]ethyl]-2-(3,5-dimethylphenyl)-1H-indol-5-yl]-2-methylpropionic acid ethyl ester

: 192643-88-2
2-[3-[2-[benzyloxycarbonyl-[4-(pyridin-3-yl)butyl]amino]ethyl]-2-(3,5-dimethylphenyl)-1H-indol-5-yl]-2-methylpropionic acid

Guidance literature:: With hydrogenchloride; In tetrahydrofuran; methanol; potassium hydroxide;

Reference yield:

: 192643-87-1
2-[3-[2-[benzyloxycarbonyl-[4-(pyridin-3-yl)butyl]amino]ethyl]-2-(3,5-dimethylphenyl)-1H-indol-5-yl]-2-methylpropionic acid ethyl ester

: 192643-88-2
2-[3-[2-[benzyloxycarbonyl-[4-(pyridin-3-yl)butyl]amino]ethyl]-2-(3,5-dimethylphenyl)-1H-indol-5-yl]-2-methylpropionic acid

Guidance literature:: With potassium hydroxide; In methanol; Heating;
DOI:10.1016/S0960-894X(01)00275-X

Reference yield:

: 60753-14-2
3-(4-hydroxybutyl)-pyridine

: 192643-88-2
2-[3-[2-[benzyloxycarbonyl-[4-(pyridin-3-yl)butyl]amino]ethyl]-2-(3,5-dimethylphenyl)-1H-indol-5-yl]-2-methylpropionic acid

Guidance literature:: Multi-step reaction with 5 steps

1: (COCl)2; Et₃N; DMSO / CH₂Cl₂ / -65 - -60 °C

2: Mg₂SO₄ / CDCl₃ / -10 - -5 °C

3: NaBH₄ / methanol / -5 °C

4: i-Pr₂NEt / CH₂Cl₂; tetrahydrofuran / -78 °C

5: aq. KOH / methanol / Heating

With potassium hydroxide; sodium tetrahydroborate; oxalyl dichloride; magnesium sulfate; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; chloroform-d1; dichloromethane;
DOI:10.1016/S0960-894X(01)00275-X