2-[2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-3-yl)butylamino]ethyl]-1H-indol-5-yl]-2-methylpropionic acid ethyl ester

Base Information

Chemical Name:2-[2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-3-yl)butylamino]ethyl]-1H-indol-5-yl]-2-methylpropionic acid ethyl ester
CAS No.:192643-85-9
Molecular Formula:C₃₃H₄₁N₃O₂
Molecular Weight:511.707
Hs Code.:

Synonyms:2-[2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-3-yl)butylamino]ethyl]-1H-indol-5-yl]-2-methylpropionic acid ethyl ester

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Chemical Property of 2-[2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-3-yl)butylamino]ethyl]-1H-indol-5-yl]-2-methylpropionic acid ethyl ester

Chemical Property:

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Technology Process of 2-[2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-3-yl)butylamino]ethyl]-1H-indol-5-yl]-2-methylpropionic acid ethyl ester

There total 4 articles about 2-[2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-3-yl)butylamino]ethyl]-1H-indol-5-yl]-2-methylpropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 145912-93-2
4-(3-pyridinyl)butyraldehyde

: 192643-90-6
ethyl 2-(4-hydrazinophenyl)-2-methylpropanoate

: 192643-86-0
2-[3-(2-aminoethyl)-2-(3,5-dimethyl-phenyl)-1H-indol-5-yl]-2-methylpropionic acid ethyl ester

: 192643-85-9
2-[2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-3-yl)butylamino]ethyl]-1H-indol-5-yl]-2-methylpropionic acid ethyl ester

Guidance literature:: With sodium borohydrid; magnesium sulfate; In methanol; chloroform-d1; dichloromethane; water; ethyl acetate;

Reference yield:

: 2-{2-(3,5-dimethyl-phenyl)-3-[2-(4-pyridin-3-yl-butylideneamino)-ethyl]-1H-indol-5-yl}-2-methyl-propionic acid ethyl ester

: 192643-85-9
2-[2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-3-yl)butylamino]ethyl]-1H-indol-5-yl]-2-methylpropionic acid ethyl ester

Guidance literature:: With sodium tetrahydroborate; In methanol; at -5 ℃;
DOI:10.1016/S0960-894X(01)00275-X

Reference yield:

: 60753-14-2
3-(4-hydroxybutyl)-pyridine

: 192643-85-9
2-[2-(3,5-dimethylphenyl)-3-[2-[4-(pyridin-3-yl)butylamino]ethyl]-1H-indol-5-yl]-2-methylpropionic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: (COCl)2; Et₃N; DMSO / CH₂Cl₂ / -65 - -60 °C

2: Mg₂SO₄ / CDCl₃ / -10 - -5 °C

3: NaBH₄ / methanol / -5 °C

With sodium tetrahydroborate; oxalyl dichloride; magnesium sulfate; dimethyl sulfoxide; triethylamine; In methanol; chloroform-d1; dichloromethane;
DOI:10.1016/S0960-894X(01)00275-X