(2R)-2-{[2-chloro-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol

Base Information

Chemical Name:(2R)-2-{[2-chloro-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol
CAS No.:911715-72-5
Molecular Formula:C₂₀H₂₅ClN₄O₃S₃
Molecular Weight:501.094
Hs Code.:

Synonyms:(2R)-2-{[2-chloro-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol

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Chemical Property of (2R)-2-{[2-chloro-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol

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Technology Process of (2R)-2-{[2-chloro-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol

There total 5 articles about (2R)-2-{[2-chloro-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 911715-71-4
(2R)-2-{[2-amino-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol

: 911715-72-5
(2R)-2-{[2-chloro-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol

Guidance literature:: (2R)-2-{[2-amino-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol; With hydrogenchloride; sodium nitrite; In water; acetonitrile; at 0 ℃;

With sodium hydrogencarbonate; In water; acetonitrile; at 0 ℃;

Reference yield:

: 463954-32-7
(2R)-2-[(2-amino-5-sulfanyl[1,3]thiazolo[4,5-d]pyrimidin-7-yl)-amino]-4-methylpentan-1-ol

: 911715-72-5
(2R)-2-{[2-chloro-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 40 °C

2.1: hydrogenchloride; sodium nitrite / water; acetonitrile / 0 °C

2.2: 0 °C

With hydrogenchloride; sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; sodium nitrite; In water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 911715-70-3
3-[(1S)-1-chloroethyl]phenyl methyl sulfone

: 911715-72-5
(2R)-2-{[2-chloro-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 40 °C

2.1: hydrogenchloride; sodium nitrite / water; acetonitrile / 0 °C

2.2: 0 °C

With hydrogenchloride; sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; sodium nitrite; In water; dimethyl sulfoxide; acetonitrile;