(2R)-2-{[2-methoxy-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]-thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol

Base Information

Chemical Name:(2R)-2-{[2-methoxy-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]-thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol
CAS No.:911715-73-6
Molecular Formula:C₂₁H₂₈N₄O₄S₃
Molecular Weight:496.676
Hs Code.:

Synonyms:(2R)-2-{[2-methoxy-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]-thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol

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Chemical Property of (2R)-2-{[2-methoxy-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]-thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol

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Technology Process of (2R)-2-{[2-methoxy-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]-thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol

There total 6 articles about (2R)-2-{[2-methoxy-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]-thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 67-56-1
methanol

: 911715-72-5
(2R)-2-{[2-chloro-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol

: 911715-73-6
(2R)-2-{[2-methoxy-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]-thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol

Guidance literature:: With potassium hydroxide; at 0 ℃;

Reference yield:

: 463954-32-7
(2R)-2-[(2-amino-5-sulfanyl[1,3]thiazolo[4,5-d]pyrimidin-7-yl)-amino]-4-methylpentan-1-ol

: 911715-73-6
(2R)-2-{[2-methoxy-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]-thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 40 °C

2.1: hydrogenchloride; sodium nitrite / water; acetonitrile / 0 °C

2.2: 0 °C

3.1: potassium hydroxide / 0 °C

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; sodium nitrite; In water; dimethyl sulfoxide; acetonitrile;

Reference yield:

: 911715-70-3
3-[(1S)-1-chloroethyl]phenyl methyl sulfone

: 911715-73-6
(2R)-2-{[2-methoxy-5-({(1R)-1-[3-(methylsulfonyl)phenyl]ethyl}thio)[1,3]-thiazolo[4,5-d]pyrimidin-7-yl]amino}-4-methylpentan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 40 °C

2.1: hydrogenchloride; sodium nitrite / water; acetonitrile / 0 °C

2.2: 0 °C

3.1: potassium hydroxide / 0 °C

With hydrogenchloride; potassium hydroxide; sodium tetrahydroborate; N-ethyl-N,N-diisopropylamine; sodium nitrite; In water; dimethyl sulfoxide; acetonitrile;