Wy 49322

Base Information

• Chemical Name: Wy 49322
• CAS No.: 117293-55-7
• Molecular Formula: C₁₆H₈F₁₅N₅O
• Molecular Weight: 571.248
• Mol file: 117293-55-7.mol

Synonyms:Wy 49322

Chemical Property of Wy 49322

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Wy 49322

There total 5 articles about Wy 49322 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecafluoro-octanoic acid (4-cyanomethyl-phenyl)-amide (117897-75-3) → Wy 49322 (117293-55-7)

Guidance literature:

With sodium azide; ammonium chloride; In N,N-dimethyl-formamide; at 135 ℃;

DOI:10.1021/jm00121a003

Reference yield:

p-aminophenylacetonitrile (3544-25-0) → Wy 49322 (117293-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1: EtOCCH / ethyl acetate / 15 h / 85 °C

2: NaN₃, NH₄Cl / dimethylformamide / 135 °C

With sodium azide; ammonium chloride; 1-ethoxyacetylene; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm00121a003

Reference yield:

pentadecafluorooctanoyl chloride (335-64-8) → Wy 49322 (117293-55-7)

Guidance literature:

Multi-step reaction with 2 steps

1: EtN(iPr)2 / CH₂Cl₂ / 0 °C

2: NaN₃, NH₄Cl / dimethylformamide / 135 °C

With sodium azide; ammonium chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm00121a003

upstream raw materials:

2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecafluoro-octanoic acid (4-cyanomethyl-phenyl)-amide

p-aminophenylacetonitrile

pentadecafluorooctanoyl chloride

Perfluorooctanoic acid

Downstream raw materials:

2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecafluoro-octanoic acid methyl-[4-(2-methyl-2H-tetrazol-5-ylmethyl)-phenyl]-amide

2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecafluoro-octanoic acid methyl-[4-(1-methyl-1H-tetrazol-5-ylmethyl)-phenyl]-amide

2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluoro-N-<4-(1H-tetrazol-5-ylmethyl)phenyl>octanamine

2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-Pentadecafluoro-octanoic acid [4-(2-benzyl-2H-tetrazol-5-ylmethyl)-phenyl]-amide

Refernces

• 1、 Kees,Cheeseman,Prozialeck,Steiner. "Perfluoro-N-[4-1H-tetrazol-5-ylmethl)phenyl]alkanamides. A new class of oral antidiabetic agents". . p. 11 - 13. Retrieved 2007/10/02.