(-)-1--5-methyluracil

Base Information

• Chemical Name: (-)-1--5-methyluracil
• CAS No.: 131371-60-3
• Molecular Formula: C₂₂H₂₃N₅O₉
• Molecular Weight: 501.453
• Mol file: 131371-60-3.mol

Synonyms:(-)-1--5-methyluracil

Chemical Property of (-)-1--5-methyluracil

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-1--5-methyluracil

There total 3 articles about (-)-1--5-methyluracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(S)-Azido-((2R,3R,4R)-3,4,5-triacetoxy-tetrahydro-furan-2-yl)-acetic acid benzyl ester + 2,4-bis(trimethylsiloxy)-5-methylpyrimidine (7288-28-0) → (-)-1--5-methyluracil (131371-60-3)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In acetonitrile; at 60 ℃; for 20h;

DOI:10.1016/S0040-4020(01)87887-X

Reference yield:

benzyl bromide (100-39-0) → (-)-1--5-methyluracil (131371-60-3)

Guidance literature:

Multi-step reaction with 2 steps

2: 82 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 20 h / 60 °C

With trimethylsilyl trifluoromethanesulfonate; In acetonitrile;

DOI:10.1016/S0040-4020(01)87887-X

Reference yield:

(S)-Bromo-((2S,3S,4R)-3,4,5-triacetoxy-tetrahydro-furan-2-yl)-acetic acid (131371-61-4) → (-)-1--5-methyluracil (131371-60-3)

Guidance literature:

Multi-step reaction with 2 steps

2: 82 percent / trimethylsilyl trifluoromethanesulfonate / acetonitrile / 20 h / 60 °C

With trimethylsilyl trifluoromethanesulfonate; In acetonitrile;

DOI:10.1016/S0040-4020(01)87887-X

upstream raw materials:

2,4-bis(trimethylsiloxy)-5-methylpyrimidine

benzyl bromide

(S)-Bromo-((2S,3S,4R)-3,4,5-triacetoxy-tetrahydro-furan-2-yl)-acetic acid