5′-O-dimethoxytrityl-3′-O-tert-butyldiphenylsilyl-thio-α,β,-D-CNA(S_c,R_P)

Base Information

Chemical Name:5′-O-dimethoxytrityl-3′-O-tert-butyldiphenylsilyl-thio-α,β,-D-CNA(S_c,R_P)
CAS No.:943002-12-8
Molecular Formula:C₅₉H₆₅N₄O₁₃PSSi
Molecular Weight:1129.31
Hs Code.:

5′-O-dimethoxytrityl-3′-O-tert-butyldiphenylsilyl-thio-α,β,-D-CNA(S<sub>c</sub>,R<sub>P</sub>)

Synonyms:5′-O-dimethoxytrityl-3′-O-tert-butyldiphenylsilyl-thio-α,β,-D-CNA(S_c,R_P)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5′-O-dimethoxytrityl-3′-O-tert-butyldiphenylsilyl-thio-α,β,-D-CNA(S_c,R_P)

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Technology Process of 5′-O-dimethoxytrityl-3′-O-tert-butyldiphenylsilyl-thio-α,β,-D-CNA(S_c,R_P)

There total 3 articles about 5′-O-dimethoxytrityl-3′-O-tert-butyldiphenylsilyl-thio-α,β,-D-CNA(S_c,R_P) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 943002-10-6
cyanoethyl 3'-O-(5'-O-dimethoxytrityl)thymidinyl-5'-C(S)-tosyloxyethyl-(3'-tert-butyldiphenylsilyl)thymidinyl thiophosphoric ester

: 943002-12-8
5′-O-dimethoxytrityl-3′-O-tert-butyldiphenylsilyl-thio-α,β,-D-CNA(S_c,R_P)

Guidance literature:: With potassium carbonate; cadmium(II) chloride; In N,N-dimethyl-formamide; at 20 ℃; for 432h;
DOI:10.1002/ejoc.200601030

Reference yield:

: 494798-47-9
5′-C(S)-tosyloxyethyl-3′-O-(tert-butyldiphenylsilyl)thymidine

: 943002-12-8
5′-O-dimethoxytrityl-3′-O-tert-butyldiphenylsilyl-thio-α,β,-D-CNA(S_c,R_P)

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrazole / acetonitrile / 0.75 h / 20 °C

1.2: 320 mg / pyridine; S₈ / acetonitrile; toluene / 1 h

2.1: 95 percent / CdCl₂; K₂CO₃ / dimethylformamide / 432 h / 20 °C

With 1H-tetrazole; potassium carbonate; cadmium(II) chloride; In N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/ejoc.200601030

Reference yield:

: 943002-10-6
cyanoethyl 3'-O-(5'-O-dimethoxytrityl)thymidinyl-5'-C(S)-tosyloxyethyl-(3'-tert-butyldiphenylsilyl)thymidinyl thiophosphoric ester

: 943002-12-8
5′-O-dimethoxytrityl-3′-O-tert-butyldiphenylsilyl-thio-α,β,-D-CNA(S_c,R_P)

: 943002-13-9
C₅₉H₆₅N₄O₁₃PSSi

Guidance literature:: With triethylamine; cadmium(II) chloride; In toluene; at 90 ℃; Further Variations:; Reagents; Temperatures; Product distribution;
DOI:10.1002/ejoc.200601030