N-[3-(3-fluoro-4-pyrrol-1-yl-phenyl)-4,5-dihydro-isoxazol-5-ylmethyl]-acetamide

Base Information

Chemical Name:N-[3-(3-fluoro-4-pyrrol-1-yl-phenyl)-4,5-dihydro-isoxazol-5-ylmethyl]-acetamide
CAS No.:238743-03-8
Molecular Formula:C₁₆H₁₆FN₃O₂
Molecular Weight:301.32
Hs Code.:

<i>N</i>-[3-(3-fluoro-4-pyrrol-1-yl-phenyl)-4,5-dihydro-isoxazol-5-ylmethyl]-acetamide

Synonyms:N-[3-(3-fluoro-4-pyrrol-1-yl-phenyl)-4,5-dihydro-isoxazol-5-ylmethyl]-acetamide

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Chemical Property of N-[3-(3-fluoro-4-pyrrol-1-yl-phenyl)-4,5-dihydro-isoxazol-5-ylmethyl]-acetamide

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Technology Process of N-[3-(3-fluoro-4-pyrrol-1-yl-phenyl)-4,5-dihydro-isoxazol-5-ylmethyl]-acetamide

There total 3 articles about N-[3-(3-fluoro-4-pyrrol-1-yl-phenyl)-4,5-dihydro-isoxazol-5-ylmethyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 109-97-7,30604-81-0
pyrrole

: 238743-48-1
N-[3-(3,4-difluoro-phenyl)-4,5-dihydro-isoxazol-5-ylmethyl]-acetamide

: 238743-03-8
N-[3-(3-fluoro-4-pyrrol-1-yl-phenyl)-4,5-dihydro-isoxazol-5-ylmethyl]-acetamide

Guidance literature:: pyrrole; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

N-[3-(3,4-difluoro-phenyl)-4,5-dihydro-isoxazol-5-ylmethyl]-acetamide; In N,N-dimethyl-formamide; at 50 - 60 ℃; for 2h; Further stages.;
DOI:10.1021/jm020248u

Reference yield:

: 692-33-1
N-allylacetamide

: 238743-03-8
N-[3-(3-fluoro-4-pyrrol-1-yl-phenyl)-4,5-dihydro-isoxazol-5-ylmethyl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N / diethyl ether / 20 h / 20 °C

1.2: chiral HPLC on Chiralpak AD column

2.1: NaH / dimethylformamide / 0.33 h / 20 °C

2.2: 58 percent / dimethylformamide / 2 h / 50 - 60 °C

With sodium hydride; triethylamine; In diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm020248u

Reference yield:

: 34036-07-2
3,4 difluorobenzaldehyde

: 238743-03-8
N-[3-(3-fluoro-4-pyrrol-1-yl-phenyl)-4,5-dihydro-isoxazol-5-ylmethyl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 89 percent / NH₂OH*HCl; aq. NaOH / ethanol

2.1: 96 percent / NCS; HCl / dimethylformamide / 2 h / 20 °C

3.1: Et₃N / diethyl ether / 20 h / 20 °C

3.2: chiral HPLC on Chiralpak AD column

4.1: NaH / dimethylformamide / 0.33 h / 20 °C

4.2: 58 percent / dimethylformamide / 2 h / 50 - 60 °C

With hydrogenchloride; sodium hydroxide; N-chloro-succinimide; hydroxylamine hydrochloride; sodium hydride; triethylamine; In diethyl ether; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm020248u