4-(4-(2-(4-(1-naphthyl)piperazinyl)ethyl)phenyl)-2-amino-5-methylthiazole

Base Information

Chemical Name:4-(4-(2-(4-(1-naphthyl)piperazinyl)ethyl)phenyl)-2-amino-5-methylthiazole
CAS No.:117923-14-5
Molecular Formula:C₂₆H₂₈N₄S
Molecular Weight:428.601
Hs Code.:

Synonyms:4-(4-(2-(4-(1-naphthyl)piperazinyl)ethyl)phenyl)-2-amino-5-methylthiazole

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Chemical Property of 4-(4-(2-(4-(1-naphthyl)piperazinyl)ethyl)phenyl)-2-amino-5-methylthiazole

Chemical Property:

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Technology Process of 4-(4-(2-(4-(1-naphthyl)piperazinyl)ethyl)phenyl)-2-amino-5-methylthiazole

There total 4 articles about 4-(4-(2-(4-(1-naphthyl)piperazinyl)ethyl)phenyl)-2-amino-5-methylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57536-86-4
1-naphtylpiperazine

: 117922-96-0
4-<4-(2-chloroethyl)phenyl>-2-amino-5-methylthiazole hydrobromide

: 117923-14-5
4-(4-(2-(4-(1-naphthyl)piperazinyl)ethyl)phenyl)-2-amino-5-methylthiazole

Guidance literature:: With sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In various solvent(s); for 120h; Heating;
DOI:10.1021/jm00110a016

Reference yield:

: 622-24-2
2-phenylethyl chloride

: 117923-14-5
4-(4-(2-(4-(1-naphthyl)piperazinyl)ethyl)phenyl)-2-amino-5-methylthiazole

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / AlCl₃ / 1,2-dichloro-ethane / 0.42 h / Ambient temperature

2: Br₂, acetic acid / 1 h / Ambient temperature

3: acetone / 3 h / Heating

4: Na₂CO₃, NaI, diisopropylethylamine / various solvent(s) / 120 h / Heating

With aluminium trichloride; bromine; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium iodide; In 1,2-dichloro-ethane; acetone;
DOI:10.1021/jm00110a016

Reference yield:

: 2-Bromo-1-[4-(2-chloro-ethyl)-phenyl]-propan-1-one

: 117923-14-5
4-(4-(2-(4-(1-naphthyl)piperazinyl)ethyl)phenyl)-2-amino-5-methylthiazole

Guidance literature:: Multi-step reaction with 2 steps

1: acetone / 3 h / Heating

2: Na₂CO₃, NaI, diisopropylethylamine / various solvent(s) / 120 h / Heating

With sodium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; In acetone;
DOI:10.1021/jm00110a016