4-(2-Chloroethyl)propiophenone

Base Information

• Chemical Name: 4-(2-Chloroethyl)propiophenone
• CAS No.: 117922-95-9
• Molecular Formula: C11H13 Cl O
• Molecular Weight: 196.67
• Mol file: 117922-95-9.mol

Synonyms:4-(2-Chloroethyl)propiophenone;1-(4-(2-chloroethyl)phenyl)propan-1-one

Chemical Property of 4-(2-Chloroethyl)propiophenone

Chemical Property:

• Boiling Point: 311.7±25.0 °C(Predicted)
• PSA: 17.07000
• Density: 1.082±0.06 g/cm3(Predicted)
• LogP: 3.06060

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(2-Chloroethyl)propiophenone

There total 1 articles about 4-(2-Chloroethyl)propiophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

propionyl chloride (79-03-8) + 2-phenylethyl chloride (622-24-2) → 4-(2-chloroethyl)propiophenone (117922-95-9)

Guidance literature:

With aluminium trichloride; In 1,2-dichloro-ethane; for 0.416667h; Ambient temperature;

DOI:10.1021/jm00110a016

Reference yield:

4-(2-chloroethyl)propiophenone (117922-95-9) → 4-<4-(2-chloroethyl)phenyl>-2-amino-5-methylthiazole hydrobromide (117922-96-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Br₂, acetic acid / 1 h / Ambient temperature

2: acetone / 3 h / Heating

With bromine; acetic acid; In acetone;

DOI:10.1021/jm00110a016

Reference yield:

4-(2-chloroethyl)propiophenone (117922-95-9) → 4-(4-(2-(4-(1-naphthyl)piperazinyl)ethyl)phenyl)-2-amino-5-methylthiazole (117923-14-5)

Guidance literature:

Multi-step reaction with 3 steps

1: Br₂, acetic acid / 1 h / Ambient temperature

2: acetone / 3 h / Heating

3: Na₂CO₃, NaI, diisopropylethylamine / various solvent(s) / 120 h / Heating

With bromine; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; sodium iodide; In acetone;

DOI:10.1021/jm00110a016

upstream raw materials:

propionyl chloride

2-phenylethyl chloride

Downstream raw materials:

4-<4-(2-chloroethyl)phenyl>-2-amino-5-methylthiazole hydrobromide

4-(4-(2-(4-(1-naphthyl)piperazinyl)ethyl)phenyl)-2-amino-5-methylthiazole

Refernces

• 1、 -. "Arylpiperazinyl-alkylene-phenyl-heterocyclic compounds". . . Retrieved 2008/06/13.