5-Chloro-4-{[4'-chloro-3-(pyridazin-4-yl)-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Base Information

Chemical Name:5-Chloro-4-{[4'-chloro-3-(pyridazin-4-yl)-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide
CAS No.:1354786-39-2
Molecular Formula:C₂₅H₁₃Cl₂F₄N₅O₃S₂
Molecular Weight:642.442
Hs Code.:

Synonyms:5-Chloro-4-{[4'-chloro-3-(pyridazin-4-yl)-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

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Chemical Property of 5-Chloro-4-{[4'-chloro-3-(pyridazin-4-yl)-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

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Technology Process of 5-Chloro-4-{[4'-chloro-3-(pyridazin-4-yl)-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

There total 6 articles about 5-Chloro-4-{[4'-chloro-3-(pyridazin-4-yl)-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1354786-97-2
5-Chloro-4-(4'-chloro-3-(pyridazin-4-yl)-3'-(trifluoromethyl)biphenyl-4-yloxy)-N-(2,4-dimethoxybenzyl)-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

: 1354786-39-2
5-Chloro-4-{[4'-chloro-3-(pyridazin-4-yl)-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 50 ℃; for 6h;

Reference yield:

: 540-38-5
p-Iodophenol

: 1354786-39-2
5-Chloro-4-{[4'-chloro-3-(pyridazin-4-yl)-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 80 °C

2: sulfuric acid; acetic acid; N-iodo-succinimide / 18 h / 20 °C

3: cesium fluoride; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 0.67 h / 45 °C

4: potassium carbonate / dimethyl sulfoxide / 3 h / 20 °C

5: hydrogenchloride / 1,4-dioxane; methanol / 6 h / 50 °C

With hydrogenchloride; N-iodo-succinimide; copper(l) iodide; sulfuric acid; potassium carbonate; caesium carbonate; acetic acid; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; water; dimethyl sulfoxide; acetonitrile; 1: Suzuki Coupling / 3: Stille Coupling;

Reference yield:

: 176976-42-4
(4-chloro-3-(trifluoromethyl)phenyl)boronic acid

: 1354786-39-2
5-Chloro-4-{[4'-chloro-3-(pyridazin-4-yl)-3'-(trifluoromethyl)biphenyl-4-yl]oxy}-2-fluoro-N-(1,3,4-thiadiazol-2-yl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 1 h / 80 °C

2: sulfuric acid; acetic acid; N-iodo-succinimide / 18 h / 20 °C

3: cesium fluoride; copper(l) iodide / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / acetonitrile / 0.67 h / 45 °C

4: potassium carbonate / dimethyl sulfoxide / 3 h / 20 °C

5: hydrogenchloride / 1,4-dioxane; methanol / 6 h / 50 °C

With hydrogenchloride; N-iodo-succinimide; copper(l) iodide; sulfuric acid; potassium carbonate; caesium carbonate; acetic acid; cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; methanol; water; dimethyl sulfoxide; acetonitrile; 1: Suzuki Coupling / 3: Stille Coupling;