N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine

Base Information

Chemical Name:N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine
CAS No.:1608109-25-6
Molecular Formula:C₃₃H₃₂F₃N₃O₇S
Molecular Weight:671.694
Hs Code.:

N<SUP>4</SUP>-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine

Synonyms:N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine

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Chemical Property of N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine

Chemical Property:

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Technology Process of N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine

There total 5 articles about N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1608109-24-5
N⁴-acetyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine

: 1608109-25-6
N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine

Guidance literature:: N⁴-acetyl-3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine; With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; at 20 ℃; for 2.5h; Inert atmosphere;

Inert atmosphere;
DOI:10.1021/ja5005637

Reference yield:

: 1608109-21-2
3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiouridine

: 1608109-25-6
N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap; triethylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: ammonia / tetrahydrofuran; water / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: pyridine / 1.5 h / 0 - 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere

4.2: Inert atmosphere

With pyridine; dmap; tetrabutyl ammonium fluoride; ammonia; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1021/ja5005637

Reference yield:

: 1608109-22-3
3'-O-(tert-butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)-O⁶-(2,4,6-triisopropylbenzenesulfonyl)-2'-deoxy-2'-trifluoromethylthiouridine

: 1608109-25-6
N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)-2'-deoxy-2'-trifluoromethylthiocytidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonia / tetrahydrofuran; water / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: pyridine / 1.5 h / 0 - 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 2.5 h / 20 °C / Inert atmosphere

3.2: Inert atmosphere

With pyridine; tetrabutyl ammonium fluoride; ammonia; acetic acid; In tetrahydrofuran; water;
DOI:10.1021/ja5005637