Isopropyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-chloroacetamido)methyl]phenoxy}acetate

Base Information

Chemical Name:Isopropyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-chloroacetamido)methyl]phenoxy}acetate
CAS No.:1310698-66-8
Molecular Formula:C₃₀H₃₆ClN₅O₅
Molecular Weight:582.099
Hs Code.:

Synonyms:Isopropyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-chloroacetamido)methyl]phenoxy}acetate

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Chemical Property of Isopropyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-chloroacetamido)methyl]phenoxy}acetate

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Technology Process of Isopropyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-chloroacetamido)methyl]phenoxy}acetate

There total 10 articles about Isopropyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-chloroacetamido)methyl]phenoxy}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1310698-65-7
Isopropyl 2-[3-({3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propylamino}methyl)phenoxy]acetate

: 79-04-9
chloroacetyl chloride

: 1310698-66-8
Isopropyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-chloroacetamido)methyl]phenoxy}acetate

Guidance literature:: In chloroform; at 0 ℃; for 15h;

Reference yield:

: 611-36-9
quinolin-4-ol

: 1310698-66-8
Isopropyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-chloroacetamido)methyl]phenoxy}acetate

Guidance literature:: Multi-step reaction with 10 steps

1: nitric acid / propionic acid / 3.67 h / Reflux

2: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 2.5 h / Reflux

3: triethylamine / dichloromethane / 0 °C

4: sodium tetrahydroborate / nickel(II) chloride hexahydrate / methanol / 5 - 23 °C

5: hydrogenchloride; benzotriazol-1-ol / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C / Inert atmosphere

6: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 - 20 °C

7: ammonium hydroxide; p-toluenesulfonyl chloride / dichloromethane / 0 - 20 °C

8: hydrogenchloride / water; methanol / 1 h / 50 °C

9: sodium cyanoborohydride; acetic acid / methanol / 4 h / 20 °C

10: chloroform / 15 h / 0 °C

With hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; thionyl chloride; nitric acid; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; triethylamine; N,N-dimethyl-formamide; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; nickel(II) chloride hexahydrate; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; chloroform; water; propionic acid;

Reference yield:

: 50332-66-6
3-nitro-quinolin-4-ol

: 1310698-66-8
Isopropyl 2-{3-[(N-{3-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c]quinolin-1-yl]propyl}-2-chloroacetamido)methyl]phenoxy}acetate

Guidance literature:: Multi-step reaction with 9 steps

1: N,N-dimethyl-formamide; thionyl chloride / dichloromethane / 2.5 h / Reflux

2: triethylamine / dichloromethane / 0 °C

3: sodium tetrahydroborate / nickel(II) chloride hexahydrate / methanol / 5 - 23 °C

4: hydrogenchloride; benzotriazol-1-ol / 1-methyl-pyrrolidin-2-one / 4 h / 120 °C / Inert atmosphere

5: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 5 - 20 °C

6: ammonium hydroxide; p-toluenesulfonyl chloride / dichloromethane / 0 - 20 °C

7: hydrogenchloride / water; methanol / 1 h / 50 °C

8: sodium cyanoborohydride; acetic acid / methanol / 4 h / 20 °C

9: chloroform / 15 h / 0 °C

With hydrogenchloride; ammonium hydroxide; sodium tetrahydroborate; thionyl chloride; sodium cyanoborohydride; benzotriazol-1-ol; acetic acid; triethylamine; N,N-dimethyl-formamide; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; nickel(II) chloride hexahydrate; In 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; chloroform; water;