tert-butyl 4-((3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)phenyl sulfonamido)methyl)piperidine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-((3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)phenyl sulfonamido)methyl)piperidine-1-carboxylate
CAS No.:1552310-67-4
Molecular Formula:C₂₉H₃₂Cl₂N₄O₅S
Molecular Weight:619.569
Hs Code.:

Synonyms:tert-butyl 4-((3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)phenyl sulfonamido)methyl)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-((3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)phenyl sulfonamido)methyl)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-((3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)phenyl sulfonamido)methyl)piperidine-1-carboxylate

There total 8 articles about tert-butyl 4-((3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)phenyl sulfonamido)methyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 879088-41-2
4-chloro-3-(pyridin-2-yl)benzeneamine

: 1552310-66-3
4-(N-((1-(tert-butoxycarbonyl)piperidin-4-yl)methyl)sulfamoyl)-2-chlorobenzoic acid

: 1552310-67-4
tert-butyl 4-((3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)phenyl sulfonamido)methyl)piperidine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 99-60-5
2-chloro-4-nitrobenzoic acid

: 1552310-67-4
tert-butyl 4-((3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)phenyl sulfonamido)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: iron; ammonium chloride / water; ethanol / 2 h / Reflux

2.1: hydrogenchloride; sodium nitrite / water; acetic acid / 1 h / -10 - -5 °C

2.2: 0.5 h / 0 - 10 °C

3.1: triethylamine / dichloromethane / 20 °C

4.1: lithium hydroxide / water; tetrahydrofuran / 3 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; iron; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; sodium nitrite; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 61953-04-6
2-chloro-4-(chlorosulfonyl)benzoic acid

: 1552310-67-4
tert-butyl 4-((3-chloro-4-(4-chloro-3-(pyridin-2-yl)phenylcarbamoyl)phenyl sulfonamido)methyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 20 °C

2: lithium hydroxide / water; tetrahydrofuran / 3 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

With triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;