N,3-dihydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinamide

Base Information

Chemical Name:N,3-dihydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinamide
CAS No.:1198620-45-9
Molecular Formula:C₁₆H₁₈N₂O₆
Molecular Weight:334.329
Hs Code.:

Synonyms:N,3-dihydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinamide

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Chemical Property of N,3-dihydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinamide

Chemical Property:

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Technology Process of N,3-dihydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinamide

There total 5 articles about N,3-dihydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1198621-15-6
methyl 3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinate

: 1198620-45-9
N,3-dihydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinamide

Guidance literature:: With hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; at 80 ℃; for 1.5h;

Reference yield:

: 252987-04-5
(5-{[(4-methoxybenzyl)oxy]methyl}-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridin-8-yl)methanol

: 1198620-45-9
N,3-dihydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 4 h / Reflux

2.1: iodine; potassium hydroxide / 0 - 23 °C

2.2: 4 h / 20 °C

3.1: formic acid / 1 h / 20 °C

4.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol / 1.5 h / 80 °C

With formic acid; hydroxylamine hydrochloride; iodine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In methanol; ethyl acetate;

Reference yield:

: 1198621-14-5
methyl 5-((4-methoxybenzyloxy)methyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxylate

: 1198620-45-9
N,3-dihydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinamide

Guidance literature:: Multi-step reaction with 2 steps

1: formic acid / 1 h / 20 °C

2: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / methanol / 1.5 h / 80 °C

With formic acid; hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol;