methyl 3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinate

Base Information

• Chemical Name: methyl 3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinate
• CAS No.: 1198621-15-6
• Molecular Formula: C₁₇H₁₉NO₆
• Molecular Weight: 333.341
• Mol file: 1198621-15-6.mol

Synonyms:methyl 3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinate

Chemical Property of methyl 3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinate

There total 8 articles about methyl 3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 5-((4-methoxybenzyloxy)methyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxylate (1198621-14-5) → methyl 3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinate (1198621-15-6)

Guidance literature:

methyl 5-((4-methoxybenzyloxy)methyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxylate; With hydrogenchloride; In methanol; at 23 ℃; for 24h;

With sodium hydrogencarbonate; In methanol;

Reference yield:

5-{[(4-methoxybenzyl)oxy]methyl}-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carbaldehyde (280762-58-5) → methyl 3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinate (1198621-15-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: iodine; potassium hydroxide / 0 - 23 °C

1.2: 4 h / 20 °C

2.1: formic acid / 1 h / 20 °C

With formic acid; iodine; potassium hydroxide;

Reference yield:

(5-{[(4-methoxybenzyl)oxy]methyl}-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridin-8-yl)methanol (252987-04-5) → methyl 3-hydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinate (1198621-15-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 4 h / Reflux

2.1: iodine; potassium hydroxide / 0 - 23 °C

2.2: 4 h / 20 °C

3.1: formic acid / 1 h / 20 °C

With formic acid; iodine; potassium hydroxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In ethyl acetate;

upstream raw materials:

methyl 5-((4-methoxybenzyloxy)methyl)-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carboxylate

5-{[(4-methoxybenzyl)oxy]methyl}-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridine-8-carbaldehyde

(5-{[(4-methoxybenzyl)oxy]methyl}-2,2-dimethyl-4H-[1,3]dioxino[4,5-c]pyridin-8-yl)methanol

5-{[(4-methoxybenzyl)oxy]methyl}-2,2,8-trimethyl-4H-[1,3]dioxino[4,5-c]pyridine

Downstream raw materials:

N,3-dihydroxy-4-(hydroxymethyl)-5-((4-methoxybenzyloxy)methyl)picolinamide

(4-fluoro-benzyl)-(5-hydroxy-6-hydroxycarbamoyl-4-methyl-pyridin-3-ylmethyl)-carbamic acid benzyl ester

3-hydroxy-4-methyl-pyridine-2,5-dicarboxylic acid 5-(3-chloro-4-fluoro-benzylamide) 2-hydroxyamide

5-[(4-fluoro-benzylamino)-methyl]-3-hydroxy-4-methyl-pyridine-2-carboxylic acid methyl ester