methyl cis-2,3,4,4a,5,10b-hexahydro-10-<(p-methoxyphenyl)sulfonyl>-1H-pyrrolo<2,3-a>carbazole-1-carboxylate

Base Information

Chemical Name:methyl cis-2,3,4,4a,5,10b-hexahydro-10-<(p-methoxyphenyl)sulfonyl>-1H-pyrrolo<2,3-a>carbazole-1-carboxylate
CAS No.:88939-76-8
Molecular Formula:C₂₃H₂₄N₂O₅S
Molecular Weight:440.52
Hs Code.:

Synonyms:methyl cis-2,3,4,4a,5,10b-hexahydro-10-<(p-methoxyphenyl)sulfonyl>-1H-pyrrolo<2,3-a>carbazole-1-carboxylate

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Chemical Property of methyl cis-2,3,4,4a,5,10b-hexahydro-10-<(p-methoxyphenyl)sulfonyl>-1H-pyrrolo<2,3-a>carbazole-1-carboxylate

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Technology Process of methyl cis-2,3,4,4a,5,10b-hexahydro-10-<(p-methoxyphenyl)sulfonyl>-1H-pyrrolo<2,3-a>carbazole-1-carboxylate

There total 5 articles about methyl cis-2,3,4,4a,5,10b-hexahydro-10-<(p-methoxyphenyl)sulfonyl>-1H-pyrrolo<2,3-a>carbazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 88939-71-3
But-3-enyl-[1-[1-(4-methoxy-benzenesulfonyl)-3-methyl-1H-indol-2-yl]-meth-(E)-ylidene]-amine

: 79-22-1
methyl chloroformate

: 88939-76-8
methyl cis-2,3,4,4a,5,10b-hexahydro-10-<(p-methoxyphenyl)sulfonyl>-1H-pyrrolo<2,3-a>carbazole-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In chlorobenzene; 1.) 20 deg C, 15 min; 2.) reflux, 1 h;
DOI:10.1016/S0040-4020(01)88612-9

Reference yield:

: 83-34-1
3-Methylindole

: 88939-76-8
methyl cis-2,3,4,4a,5,10b-hexahydro-10-<(p-methoxyphenyl)sulfonyl>-1H-pyrrolo<2,3-a>carbazole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH/mineral oil / 1.) THF, 5 deg C, 15 min; 20 deg C, 15 min; reflux, 1 h; 2.) THF, 20 deg C, 1 h

2: 66 percent / SnCl₄ / CH₂Cl₂ / 2 h / -25 °C

3: CH₂Cl₂ / 6 h / 20 °C

4: 84 percent / N(i-Pr)2Et / chlorobenzene / 1.) 20 deg C, 15 min; 2.) reflux, 1 h

With tin(IV) chloride; sodium hydride; N-ethyl-N,N-diisopropylamine; mineral oil; In dichloromethane; chlorobenzene;
DOI:10.1016/S0040-4020(01)88612-9

Reference yield:

: 88939-68-8
1-<(p-methoxyphenyl)sulfonyl>-3-methylindole

: 88939-76-8
methyl cis-2,3,4,4a,5,10b-hexahydro-10-<(p-methoxyphenyl)sulfonyl>-1H-pyrrolo<2,3-a>carbazole-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / SnCl₄ / CH₂Cl₂ / 2 h / -25 °C

2: CH₂Cl₂ / 6 h / 20 °C

3: 84 percent / N(i-Pr)2Et / chlorobenzene / 1.) 20 deg C, 15 min; 2.) reflux, 1 h

With tin(IV) chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; chlorobenzene;
DOI:10.1016/S0040-4020(01)88612-9