5-[[(2,3-difluorophenyl)methyl]thio]-7-[[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]amino]-3-[2-(phenylsulfonyl)ethyl]-thiazolo[4,5-d]pyrimidin-2(3H)-one

Base Information

• Chemical Name: 5-[[(2,3-difluorophenyl)methyl]thio]-7-[[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]amino]-3-[2-(phenylsulfonyl)ethyl]-thiazolo[4,5-d]pyrimidin-2(3H)-one
• CAS No.: 855476-63-0
• Molecular Formula: C₂₄H₂₄F₂N₄O₅S₃
• Molecular Weight: 582.673

Synonyms:5-[[(2,3-difluorophenyl)methyl]thio]-7-[[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]amino]-3-[2-(phenylsulfonyl)ethyl]-thiazolo[4,5-d]pyrimidin-2(3H)-one

Chemical Property of 5-[[(2,3-difluorophenyl)methyl]thio]-7-[[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]amino]-3-[2-(phenylsulfonyl)ethyl]-thiazolo[4,5-d]pyrimidin-2(3H)-one

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Technology Process of 5-[[(2,3-difluorophenyl)methyl]thio]-7-[[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]amino]-3-[2-(phenylsulfonyl)ethyl]-thiazolo[4,5-d]pyrimidin-2(3H)-one

There total 1 articles about 5-[[(2,3-difluorophenyl)methyl]thio]-7-[[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]amino]-3-[2-(phenylsulfonyl)ethyl]-thiazolo[4,5-d]pyrimidin-2(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

5-[[(2,3-difluorophenyl)methyl]thio]-3-[2-(phenylsulfonyl)ethyl]-7-[(2,2,5-trimethyl-1,3-dioxan-5-yl)amino]-thiazolo[4,5-d]pyrimidin-2(3H)-one (855476-62-9) → 5-[[(2,3-difluorophenyl)methyl]thio]-7-[[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]amino]-3-[2-(phenylsulfonyl)ethyl]-thiazolo[4,5-d]pyrimidin-2(3H)-one (855476-63-0)

Guidance literature:

With hydrogenchloride; water; In tetrahydrofuran;

Reference yield: 86.0%

5-[[(2,3-difluorophenyl)methyl]thio]-7-[[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]amino]-3-[2-(phenylsulfonyl)ethyl]-thiazolo[4,5-d]pyrimidin-2(3H)-one (855476-63-0) + potassium methanolate (865-33-8) → 5-[[(2,3-difluorophenyl)methyl]thio]-7-[[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]amino]-thiazolo[4,5-d]pyrimidin-2(3H)-one potassium salt

Guidance literature:

In methanol; Heating / reflux;

Reference yield: 81.0%

5-[[(2,3-difluorophenyl)methyl]thio]-7-[[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]amino]-3-[2-(phenylsulfonyl)ethyl]-thiazolo[4,5-d]pyrimidin-2(3H)-one (855476-63-0) + sodium t-butanolate (865-48-5) → 5-[[(2,3-difluorophenyl)methyl]thio]-7-[[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]amino]-thiazolo[4,5-d]pyrimidin-2(3H)-one, monosodium salt (676345-23-6)

Guidance literature:

In isopropyl alcohol; for 1h; Heating / reflux;

upstream raw materials:

5-[[(2,3-difluorophenyl)methyl]thio]-3-[2-(phenylsulfonyl)ethyl]-7-[(2,2,5-trimethyl-1,3-dioxan-5-yl)amino]-thiazolo[4,5-d]pyrimidin-2(3H)-one

Downstream raw materials:

5-[[(2,3-difluorophenyl)methyl]thio]-7-[[2-hydroxy-1-(hydroxymethyl)-1-methylethyl]amino]-thiazolo[4,5-d]pyrimidin-2(3H)-one, monosodium salt

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