(3S,4S)-3-Acetylsulfanyl-4-[(S)-2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-6-methyl-heptanoic acid methyl ester

Base Information

• Chemical Name: (3S,4S)-3-Acetylsulfanyl-4-[(S)-2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-6-methyl-heptanoic acid methyl ester
• CAS No.: 152615-29-7
• Molecular Formula: C₂₃H₃₄N₂O₆S
• Molecular Weight: 466.599
• Mol file: 152615-29-7.mol

Synonyms:(3S,4S)-3-Acetylsulfanyl-4-[(S)-2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-6-methyl-heptanoic acid methyl ester

Chemical Property of (3S,4S)-3-Acetylsulfanyl-4-[(S)-2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-6-methyl-heptanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,4S)-3-Acetylsulfanyl-4-[(S)-2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-6-methyl-heptanoic acid methyl ester

There total 7 articles about (3S,4S)-3-Acetylsulfanyl-4-[(S)-2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-6-methyl-heptanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-amino-3-(4-methoxyphenyl)-N-methylpropionamide (96136-31-1) → (3S,4S)-3-Acetylsulfanyl-4-[(S)-2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-6-methyl-heptanoic acid methyl ester (152615-29-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / N,N-dicyclohexylcarbodiimide / CH₂Cl₂ / Ambient temperature

2: 456 h / Ambient temperature

With dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1021/jm00077a006

Reference yield:

diethyl 1,3-acetonedicarboxylate (105-50-0) → (3S,4S)-3-Acetylsulfanyl-4-[(S)-2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-6-methyl-heptanoic acid methyl ester (152615-29-7)

Guidance literature:

Multi-step reaction with 6 steps

1: 1.) magnesium ethoxide / 1.) EtOH, reflux, 90 min, 2.) EtOH, reflux, 16 h

2: 100 percent / NaBH₄ / ethanol / 2 h / 5 - 10 °C

3: 1.) P₂O₅, 2.) KOH, 3.) Ac₂O

4: 41 percent / 2 h / Heating

5: 53 percent / N,N-dicyclohexylcarbodiimide / CH₂Cl₂ / Ambient temperature

6: 456 h / Ambient temperature

With potassium hydroxide; sodium tetrahydroborate; phosphorus pentoxide; magnesium ethylate; acetic anhydride; dicyclohexyl-carbodiimide; In ethanol; dichloromethane;

DOI:10.1021/jm00077a006

Reference yield:

4-(methoxycarbonyl)-2-(2-methylpropyl)but-2-enoic acid → (3S,4S)-3-Acetylsulfanyl-4-[(S)-2-(4-methoxy-phenyl)-1-methylcarbamoyl-ethylcarbamoyl]-6-methyl-heptanoic acid methyl ester (152615-29-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 53 percent / N,N-dicyclohexylcarbodiimide / CH₂Cl₂ / Ambient temperature

2: 456 h / Ambient temperature

With dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1021/jm00077a006

upstream raw materials:

2-mercaptopropanoic acid

(S)-2-amino-3-(4-methoxyphenyl)-N-methylpropionamide

diethyl 1,3-acetonedicarboxylate

2-(2-methylpropyl)-pent-2-enedicarboxylic acid anhydride