3-(4-chlorophenyl)-6-(S)-methyl-1-[(S)-1-phenylethyl]-2-thioxotetrahydropyrimidin-4(1H)-one

Base Information

Chemical Name:3-(4-chlorophenyl)-6-(S)-methyl-1-[(S)-1-phenylethyl]-2-thioxotetrahydropyrimidin-4(1H)-one
CAS No.:1257532-06-1
Molecular Formula:C₁₉H₁₉ClN₂OS
Molecular Weight:358.892
Hs Code.:

Synonyms:3-(4-chlorophenyl)-6-(S)-methyl-1-[(S)-1-phenylethyl]-2-thioxotetrahydropyrimidin-4(1H)-one

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Chemical Property of 3-(4-chlorophenyl)-6-(S)-methyl-1-[(S)-1-phenylethyl]-2-thioxotetrahydropyrimidin-4(1H)-one

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Technology Process of 3-(4-chlorophenyl)-6-(S)-methyl-1-[(S)-1-phenylethyl]-2-thioxotetrahydropyrimidin-4(1H)-one

There total 6 articles about 3-(4-chlorophenyl)-6-(S)-methyl-1-[(S)-1-phenylethyl]-2-thioxotetrahydropyrimidin-4(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 103123-51-9,1156032-60-8
(3S,1'S)-3-<(1'-phenylethyl)amino>butanoic acid methyl ester

: 1257532-06-1
3-(4-chlorophenyl)-6-(S)-methyl-1-[(S)-1-phenylethyl]-2-thioxotetrahydropyrimidin-4(1H)-one

Guidance literature:: With lithium perchlorate; triethylamine; In acetonitrile; for 2.5h; Reflux;
DOI:10.1039/c4ra06391k

Reference yield: 53.0%

: 1156032-61-9
ethyl 3-[(S)-1-phenylethylamino]butanoate

: 2131-55-7
4-Chlorophenyl isothiocyanate

: 1257532-08-3
3-(4-chlorophenyl)-6-(R)-methyl-1-[(S)-1-phenylethyl]-2-thioxotetrahydropyrimidin-4(1H)-one

: 1257532-06-1
3-(4-chlorophenyl)-6-(S)-methyl-1-[(S)-1-phenylethyl]-2-thioxotetrahydropyrimidin-4(1H)-one

Guidance literature:: With lithium perchlorate; triethylamine; In acetonitrile; for 1.2h; optical yield given as %de; diastereoselective reaction; Reflux;
DOI:10.1039/c0ob00230e

Reference yield:

: 2627-86-3
(S)-1-phenyl-ethylamine

: 1257532-06-1
3-(4-chlorophenyl)-6-(S)-methyl-1-[(S)-1-phenylethyl]-2-thioxotetrahydropyrimidin-4(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: magnesium(II) perchlorate / methanol / 2 h / 20 °C

2.1: sodium tetrahydroborate / 2.5 h

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -78 - 0 °C

3.2: 0.25 h / -78 °C

4.1: ammonium cerium (IV) nitrate / acetonitrile; water / 2 h / 20 °C

5.1: lithium perchlorate; triethylamine / acetonitrile / 2.5 h / Reflux

With sodium tetrahydroborate; n-butyllithium; ammonium cerium (IV) nitrate; magnesium(II) perchlorate; lithium perchlorate; triethylamine; In tetrahydrofuran; methanol; hexane; water; acetonitrile;
DOI:10.1039/c4ra06391k