N-(3-(imidazol-1-yl)propyl)-N'-4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-ylurea

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Chemical Name:N-(3-(imidazol-1-yl)propyl)-N'-4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-ylurea
CAS No.:1229607-17-3
Molecular Formula:C₃₇H₃₉N₉O₃
Molecular Weight:657.775
Hs Code.:

Synonyms:N-(3-(imidazol-1-yl)propyl)-N'-4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-ylurea

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Chemical Property of N-(3-(imidazol-1-yl)propyl)-N'-4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-ylurea

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Technology Process of N-(3-(imidazol-1-yl)propyl)-N'-4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-ylurea

There total 4 articles about N-(3-(imidazol-1-yl)propyl)-N'-4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-ylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 109-02-4
4-methyl-morpholine

: 57933-83-2
Isopropenyl chloroformate

: 1229607-74-2
prop-1-en-2-yl 4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-ylcarbamate

: 1229607-17-3
N-(3-(imidazol-1-yl)propyl)-N'-4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-ylurea

Guidance literature:: With ammonia; SiO₂; In tetrahydrofuran; methanol; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; ethyl acetate;

Reference yield:

: 285984-25-0,1244948-94-4
3-tert-butyl-1-p-tolyl-1H-pyrazol-5-amine

: 1229607-17-3
N-(3-(imidazol-1-yl)propyl)-N'-4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-ylurea

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / dichloromethane; water / 0 °C

1.2: 1.33 h / 0 °C

1.3: 0 °C / Inert atmosphere

2.1: 4-methyl-morpholine / tetrahydrofuran / 18 h / -78 - 20 °C

3.1: 4-methyl-morpholine / tetrahydrofuran / 16 h / 55 °C

With 4-methyl-morpholine; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 1229607-44-6
4-(4-aminonaphthalen-1-yloxy)pyridin-2-amine

: 1229607-17-3
N-(3-(imidazol-1-yl)propyl)-N'-4-(4-(3-(3-tert-butyl-1-p-tolyl-1H-pyrazol-5-yl)ureido)naphthalen-1-yloxy)pyridin-2-ylurea

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / dichloromethane; water / 0 °C

1.2: 1.33 h / 0 °C

1.3: 0 °C / Inert atmosphere

2.1: 4-methyl-morpholine / tetrahydrofuran / 18 h / -78 - 20 °C

3.1: 4-methyl-morpholine / tetrahydrofuran / 16 h / 55 °C

With 4-methyl-morpholine; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane; water;