3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-methylbenzonitrile

Base Information

Chemical Name:3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-methylbenzonitrile
CAS No.:1383983-58-1
Molecular Formula:C₂₆H₂₈N₄O
Molecular Weight:412.535
Hs Code.:

Synonyms:3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-methylbenzonitrile

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Chemical Property of 3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-methylbenzonitrile

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Technology Process of 3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-methylbenzonitrile

There total 8 articles about 3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-methylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1383985-94-1
(1r,4r)-4-methoxy-5''-methyl-6'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

: 124289-21-0
3-bromo-5-methylbenzonitrile

: 1383983-58-1
3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-methylbenzonitrile

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 130 ℃; for 0.333333h; Sealed vial; Inert atmosphere;

Reference yield:

: 1383985-58-7
6'-bromo-4-methoxyspiro[cyclohexane-1,2'-inden]-1'(3'H)-imine

: 1383983-58-1
3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-methylbenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 15 h / 60 °C / Inert atmosphere

2: ammonia / methanol / 74 °C

3: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.33 h / 110 °C / Microwave irradiation; Sealed vessel

4: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 130 °C / Sealed vial; Inert atmosphere

With ammonia; potassium acetate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; methanol; water;

Reference yield:

: 1245515-16-5
6'-bromo-4-methoxyspiro[cyclohexane-1,2'-indene]-1'(3'H)-one

: 1383983-58-1
3-[(1r,4r)-4''-amino-4-methoxy-5''-methyl-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-6'-yl]-5-methylbenzonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: titanium(IV) tetraethanolate / 2-methyltetrahydrofuran / 26 h / Reflux

2: hydrogenchloride / 1,4-dioxane / 1.5 h / 20 °C / Inert atmosphere

3: methanol / 15 h / 60 °C / Inert atmosphere

4: ammonia / methanol / 74 °C

5: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 0.33 h / 110 °C / Microwave irradiation; Sealed vessel

6: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.33 h / 130 °C / Sealed vial; Inert atmosphere

With hydrogenchloride; titanium(IV) tetraethanolate; ammonia; potassium acetate; potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 2-methyltetrahydrofuran; 1,4-dioxane; methanol; water;