124289-21-0

Basic information

• Product Name: 3-BROMO-5-METHYLBENZONITRILE
• Synonyms: 3-BROMO-5-METHYLBENZONITRILE;3-Methyl-5-bromobenzonitrile;3-BroMo-5-Methylbenzonitrile, 95+%;Benzonitrile,3-bromo-5-methyl-;Bromo-5-methyl-benzonitrile
• CAS NO: 124289-21-0
• Molecular Formula: C₈H₆BrN
• Molecular Weight: 196.04
• Mol File: 124289-21-0.mol
• Article Data: 14

Chemical Properties

• Melting Point: 57-58.5℃
• Boiling Point: 256.1±20.0℃ (760 Torr)
• Flash Point: 108.7±21.8℃
• Appearance: /
• Density: 1.51±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.016mmHg at 25°C
• Refractive Index: 1.591
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 3-BROMO-5-METHYLBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-5-METHYLBENZONITRILE(124289-21-0)
• EPA Substance Registry System: 3-BROMO-5-METHYLBENZONITRILE(124289-21-0)

Safety Data

• Hazardous Substances Data: 124289-21-0(Hazardous Substances Data)

Usage

Uses

3-Bromo-5-methylbenzonitrile is used in the synthesis of arenes with high steric regiocontrol.

InChI:InChI=1/C8H6BrN/c1-6-2-7(5-10)4-8(9)3-6/h2-4H,1H3

Upstream product

• 1611-92-3 3,5-dibromotoluene 
• 141-78-6 ethyl acetate 
• 544-92-3 copper(I) cyanide 
• 1583285-83-9 C₂₀H₃₉BO₄Si₃ 
• 253342-48-2 4,4,5,5-tetramethyl-2-m-tolyl-1,3,2-dioxaborolane 
• 648439-19-4 (3-bromo-5-methylphenyl)methanol 
• 51719-69-8 1-bromo-3-(bromomethyl)-5-methylbenzene 
• 556-96-7 5-bromo-1,3-xylene 
• 591-17-3 meta-bromotoluene 
• 557-21-1 zinc(II) cyanide 
• 942069-53-6 2-(3-bromo-5-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1205515-03-2 3-bromo-5-methylbenzaldehyde oxime 
• 1007578-82-6 3-bromo-5-methylbenzamide 
• 13091-43-5 2-amino-3-bromo-5-methylbenzoic acid 

Downstream Products

• 124289-24-3 α-Bromo-3-bromo-5-cyanotoluene 
• 1395093-32-9 3-bromo-N-(2,6-diisopropylphenyl)-5-methylbenziimidamide 
• 1395093-33-0 2-(3-bromo-5-methyl)-1-(2,6-diisopropylphenyl)-1H-imidazole 
• 1395093-34-1 2,2'-(oxybis(3-methyl-5,1-phenylene))bis(1-(2,6-diisopropylphenyl)-1H-imidazole) 
• 1177558-49-4 3-bromo-5-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]benzonitrile 
• 1177558-50-7 3-(aminomethyl)-5-bromobenzonitrile 
• 1177558-71-2 tert-butyl (3-bromo-5-cyanobenzyl)carbamate 
• 1177558-42-7 (3-bromo-5-methylphenyl)methanamine 
• 95658-81-4 3-hydroxy-5-methylbenzonitrile 

Relevant articles and documents

INTERMOLECULAR C-H SILYLATION OF UNACTIVATED ARENES

Reaction mixtures for silvlating arene substrates and methods of using such reaction mixtures to silyiate the arene substrates are provided. Exemplary reaction mixtures include the arene substrate, a liganded metal catalyst, a hydrogen acceptor and an organic solvent. The reaction conditions allow for diverse substituents on the arene substrate.

Palladium(II)-catalyzed direct conversion of methyl arenes into aromatic nitriles

From methyl to nitrile: A mild ammoxidation method, which directly converts methyl arenes into aromatic nitriles, has been developed by using Pd(OAc) 2 and N-hydroxyphthalimide (NHPI) as the catalysts, and tert-butyl nitrite as the nitrogen source and oxidant. Copyright

Compounds and their use as BACE Inhibitors

The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI (“mild cognitive impairment”), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.