4-(8-methoxy-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate

Base Information

Chemical Name:4-(8-methoxy-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate
CAS No.:1308889-48-6
Molecular Formula:C₃₀H₃₄N₂O₇
Molecular Weight:534.609
Hs Code.:

Synonyms:4-(8-methoxy-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate

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Chemical Property of 4-(8-methoxy-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate

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Technology Process of 4-(8-methoxy-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate

There total 4 articles about 4-(8-methoxy-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 1332636-77-7
C₁₆H₂₀N₂O₄

: 92194-92-8
4-(chlorocarbonyl)-2-(3-methylbut-2-en-1-yl)phenyl acetate

: 1308889-48-6
4-(8-methoxy-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate

Guidance literature:: In pyridine; dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm200148p

Reference yield:

: 106-52-5
N-methyl-4-hydroxypiperidine

: 1308889-48-6
4-(8-methoxy-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

2: palladium on carbon; hydrogen / tetrahydrofuran

3: pyridine; dichloromethane / 2 h / 20 °C

With di-isopropyl azodicarboxylate; palladium on carbon; hydrogen; triphenylphosphine; In tetrahydrofuran; pyridine; dichloromethane; 1: Mitsunobu reaction;
DOI:10.1021/jm200148p

Reference yield:

: 1083312-86-0
benzyl 7-hydroxy-8-methoxy-2-oxo-2H-chromen-3-ylcarbamate

: 1308889-48-6
4-(8-methoxy-7-(1-methylpiperidin-4-yloxy)-2-oxo-2H-chromen-3-ylcarbamoyl)-2-(3-methylbut-2-enyl)phenyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 2 h / 20 °C

2: palladium on carbon; hydrogen / tetrahydrofuran

3: pyridine; dichloromethane / 2 h / 20 °C

With di-isopropyl azodicarboxylate; palladium on carbon; hydrogen; triphenylphosphine; In tetrahydrofuran; pyridine; dichloromethane; 1: Mitsunobu reaction;
DOI:10.1021/jm200148p